Two salonitenolide derivatives from the aerial parts of Centaurea gigantea inhibit the growth of colorectal cancer cells in vitro

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dc.authoridJaspars, Marcel/0000-0002-2426-6028
dc.authoridKong Thoo Lin, Paul/0000-0002-7090-246X
dc.contributor.authorShoeb, Mohammad
dc.contributor.authorCelik, Sezgin
dc.contributor.authorNahar, Lutfun
dc.contributor.authorMacManus, Stephen M.
dc.contributor.authorKong-Thu-lin, Paul
dc.contributor.authorJaspars, Marcel
dc.contributor.authorSarker, Satyajit D.
dc.date.accessioned2025-01-27T20:45:50Z
dc.date.available2025-01-27T20:45:50Z
dc.date.issued2007
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe cytotoxic activity of two salonitenolide derivatives, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide (or arctiopicrin, 1) and 8-O-(4-hydroxy-3-methylbutanoyl)-salonitenolide,(2), isolated and identified from the methanol extract of the aerial parts of Centaurea gigantea, was assessed by the MTT cytotoxicity assay using the colon cancer cell line, CaCo-2. The IC50 values for 1 and 2 were found to be 8.5 and 26.4 mu M, respectively.
dc.identifier.endpage125
dc.identifier.issn1934-578X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-68049085850
dc.identifier.scopusqualityQ2
dc.identifier.startpage121
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24733
dc.identifier.volume2
dc.identifier.wosWOS:000249007300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNatural Products Inc
dc.relation.ispartofNatural Product Communications
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCentaurea gigantea
dc.subjectasteraceae
dc.subject8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide
dc.subject8-O-(4-hydroxy-3methylbutanoyl)-salonitenolide
dc.subjectDPPH assay
dc.subjectbrine shrimp lethality assay
dc.subjectcolon cancer
dc.subjectMTT
dc.titleTwo salonitenolide derivatives from the aerial parts of Centaurea gigantea inhibit the growth of colorectal cancer cells in vitro
dc.typeArticle

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