Two salonitenolide derivatives from the aerial parts of Centaurea gigantea inhibit the growth of colorectal cancer cells in vitro
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Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Natural Products Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The cytotoxic activity of two salonitenolide derivatives, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide (or arctiopicrin, 1) and 8-O-(4-hydroxy-3-methylbutanoyl)-salonitenolide,(2), isolated and identified from the methanol extract of the aerial parts of Centaurea gigantea, was assessed by the MTT cytotoxicity assay using the colon cancer cell line, CaCo-2. The IC50 values for 1 and 2 were found to be 8.5 and 26.4 mu M, respectively.
Açıklama
Anahtar Kelimeler
Centaurea gigantea, asteraceae, 8-O-(3-hydroxy-2-methylpropanoyl)-salonitenolide, 8-O-(4-hydroxy-3methylbutanoyl)-salonitenolide, DPPH assay, brine shrimp lethality assay, colon cancer, MTT
Kaynak
Natural Product Communications
WoS Q Değeri
Q4
Scopus Q Değeri
Q2
Cilt
2
Sayı
2
