Bee products in the fight against Helicobacter pylori and molecular interactions

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dc.authorid0000-0003-4056-1673
dc.authorid0000-0001-6967-6306
dc.authorid0000-0003-3879-104X
dc.contributor.authorEl-Seedi, Hesham R.
dc.contributor.authorRefaey, Mohamed S.
dc.contributor.authorAbd El-Wahed, Aida A.
dc.contributor.authorAlbadawy, Aida
dc.contributor.authorKarav, Sercan
dc.contributor.authorEl-Seedi, Shaden H.
dc.contributor.authorCheng, Guiguang
dc.date.accessioned2026-02-03T12:02:40Z
dc.date.available2026-02-03T12:02:40Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGastric or duodenal ulcers can lead to upper gastrointestinal (GI) bleeding. Infection with Helicobacter pylori (H. pylori) is one of the most common infections in the world and can cause both gastric ulcers and gastric cancer. The treatment aims to eradicate H. pylori and treatment with antibiotics has made it possible to cure gastric ulcers. The most common complication of untreated peptic ulcer disease is bleeding (hematemesis, melena, and anemia), while perforation occurs in a smaller proportion of patients. In some individuals, the infection causes mucosal changes with increasing age that lead to atrophy and intestinal metaplasia. It is believed that atrophy and especially intestinal metaplasia are a prerequisite for the most common form of gastric cancer, adenocarcinoma. There is presently a demand for an alternate treatment devoid of the current strategies drawbacks including recurrence, resistance and antibiotic abuse. The current workhighlights the possibility of bee product-based treatments for preventing and eliminating H. pylori infestation. Sci-finder, Google Scholar, PubMed, ScienceDirect, Web of Science, and Scopus were used for literature screening. Terms and keywords, i.e. helicobacter pylori, epidemiology, chemotherapy, honey, propolis, bee venom, bioactive compounds, and mechanism of action were used in the search. Bee products are important alternatives that have been utilized for treating many ailments due to their diverse biochemical and biological characteristics. Various mechanisms, such as direct antibacterial, antioxidant, anti-inflammatory, and wound healing capacities, are proposed to explain the potential effect of bee products against H. pylori. The bee product's metabolites have a role in the adherence of H. pylori to stomach epithelial cells. The disruption of bacterial cell membranes and the inhibition of virulence factors are the two mechanisms behind the bee product's promising therapeutic applications against H. pylori.
dc.description.sponsorshipDeanship of Research and Graduate Studies at King Khalid University [RGP2/540/45]
dc.description.sponsorshipNational Natural Science Foundation of China [W2412103, 32472431]
dc.description.sponsorshipZhenjiang Science & Technology Program [GJ2024009]
dc.description.sponsorshipThe authors extend their appreciation to the Deanship of Research and Graduate Studies at King Khalid University for their support through Large Research Project under grant number (RGP2/540/45) . X.Z. and Z. G. thanks the fund by the National Natural Science Foundation of China (W2412103, 32472431) , Zhenjiang Science & Technology Program (GJ2024009) .
dc.identifier.doi10.1016/j.micpath.2025.107707
dc.identifier.issn0882-4010
dc.identifier.issn1096-1208
dc.identifier.pmid40378976
dc.identifier.scopus2-s2.0-105005438546
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.micpath.2025.107707
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34819
dc.identifier.volume205
dc.identifier.wosWOS:001502033700001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherAcademic Press Ltd- Elsevier Science Ltd
dc.relation.ispartofMicrobial Pathogenesis
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectHoney
dc.subjectPropolis
dc.subjectBee venom
dc.subjectBioactive compounds
dc.subjectMechanism
dc.subjectH. pylori
dc.titleBee products in the fight against Helicobacter pylori and molecular interactions
dc.typeArticle

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