Influence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary

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dc.authoridKoyuncuoglu, Meral/0000-0003-1347-8110
dc.contributor.authorGol, Mert
dc.contributor.authorSaygili, Ugur
dc.contributor.authorKoyuncuoglu, Meral
dc.contributor.authorUslu, Turhan
dc.date.accessioned2025-01-27T20:32:00Z
dc.date.available2025-01-27T20:32:00Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: High-dose methotrexate (MTX) is one of the most prescribed agents in many malignant diseases affecting girls and young women of reproductive ages. This animal study directly measures the primordial follicle loss following exposure to high-dose MTX. Study Design: Nine inbred Balb/c mice aged 7-8 weeks in the study group were administered 5 gr/m(2) MTX as a single agent intraperitoneally, whereas nine mice in the control group received saline. Seven days later the mice were killed and total numbers of the primordial follicles remaining, in both ovaries were counted. Result: In the high-dose MTX group, the mean number of primordial follicles (mean +/- standard deviation) was significantly different (202 +/- 38) versus the control group (327 +/- 81.7; P = 0.002). Conclusions: Our study shows that high-dose MTX causes damage to the primordial follicles of the ovaries of mice. This result may be important because young women taking high-close MTX may suffer diminished reproductive performance and premature cessation of menses in the years following therapy.
dc.identifier.doi10.1111/j.1447-0756.2008.00945.x
dc.identifier.endpage433
dc.identifier.issn1341-8076
dc.identifier.issue3
dc.identifier.pmid19527378
dc.identifier.scopus2-s2.0-67650472501
dc.identifier.scopusqualityQ2
dc.identifier.startpage429
dc.identifier.urihttps://doi.org/10.1111/j.1447-0756.2008.00945.x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23324
dc.identifier.volume35
dc.identifier.wosWOS:000268236500005
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectmethotrexate
dc.subjectmice
dc.subjectovary
dc.titleInfluence of high-dose methotrexate therapy on the primordial follicles of the mouse ovary
dc.typeArticle

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