Immunosuppressive effect of Plantago major on the innate immunity of Galleria mellonella

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dc.authoridKAYA, Serhat/0000-0002-0984-2824
dc.contributor.authorKaya, Serhat
dc.date.accessioned2025-01-27T20:45:39Z
dc.date.available2025-01-27T20:45:39Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGreater plantain (Plantago major), a medicinal plant species, is used in folk medicine for the treatment of various diseases in many countries of the world. Different studies have shown that the bioactive components contained in the plant have a dual effect. It was also reported that in vivo and in vitro studies showed different results. The aim of the study was to determine the effects of P. major extract on the hemocyte-mediated and humoral immune responses of the invertebrate model organism Galleria mellonella, which is widely used in immune studies. In the evaluation of these effects, total hemocyte count, encapsulation, melanization, phenoloxidase, superoxide dismutase, catalase, malondialdehyde and total protein parameters were evaluated. The results of the study showed that the total hemocyte count did not change, that the encapsulation responses decreased, that the melanization responses and phenoloxidase activity increased and that the superoxide dismutase activity decreased. As a result, it was determined that high doses of P. major had negative effects on cell-mediated immunity and antioxidant defence and positive effects on melanization. High doses and continuous use of P. major may have negative effects on living things.
dc.description.sponsorshipCanakkale Onsekiz Mart University The Scientific Research Coordination Unit [FBA-2020-3251]
dc.description.sponsorshipThis study was supported by Canakkale Onsekiz Mart University The Scientific Research Coordination Unit (Grant number: FBA-2020-3251) . The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.identifier.doi10.7717/peerj.15982
dc.identifier.issn2167-8359
dc.identifier.pmid37753175
dc.identifier.scopus2-s2.0-85173844561
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.7717/peerj.15982
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24671
dc.identifier.volume11
dc.identifier.wosWOS:001077942800002
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPeerj Inc
dc.relation.ispartofPeerj
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPlantago major
dc.subjectGalleria mellonella
dc.subjectTotal hemocyte count
dc.subjectCell-mediated immune responses
dc.subjectHumoral immune responses
dc.titleImmunosuppressive effect of Plantago major on the innate immunity of Galleria mellonella
dc.typeArticle

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