Development and characterization of skin substitutes from electrospun polycaprolactone/silk fibroin

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dc.authorid0000-0003-3445-1814en_US
dc.authorscopusid36088908700en_US
dc.authorwosidM-2907-2016en_US
dc.contributor.authorYıldız, Gülşah
dc.contributor.authorArslan, Yavuz Emre
dc.contributor.authorDerkus, Burak
dc.contributor.authorSezgin, Billur
dc.contributor.authorMenceloglu, Yusuf Ziya
dc.contributor.authorBayar, Gürkan Raşit
dc.date.accessioned2024-02-21T12:19:34Z
dc.date.available2024-02-21T12:19:34Z
dc.date.issued2024en_US
dc.departmentFakülteler, Mühendislik Fakültesi, Biyomühendislik Bölümü
dc.description.abstractTissue-engineered skin substitutes have great potential to treat chronic wounds and high-degree burns. Existing solutions, such as Integra Dermal Template, are extensively used for skin defects. However, these templates are still lacking in terms of recreating the functionality of the native tissue and providing scarless healing. In this study, polycaprolactone/silk fibroin (PCL/SF)-based nanofibers with varying blends were fabricated and characterized to develop a novel skin substitute. Morphological analysis showed that the nanofiber distribution of each sample was homogenous without showing any beads. In terms of mechanical properties, all the samples other than SF showed sufficient mechanical strength. It was observed that adding a specific amount of SF into the PCL nanofiber improves the tensile strength of the samples due to the introduction of intermolecular interactions from the functional groups of SF. In addition, incorporating SF into PCL improved Young’s modulus of the PCL nanofibers since SF provides stiffness and structural integrity to the overall structure. Water contact angle analysis was performed as the hydrophilicity of a biomaterial is a significant factor in cell functionality. Each sample had a contact angle between 33° and 48°, indicating the adequate hydrophilicity of nanofibers for advanced cell proliferation other than PCL. Cell proliferation and viability studies were conducted with the seeding of primary human keratinocytes on the samples. It was examined that scaffolds containing blends of PCL and SF resulted in higher cell proliferation and viability after 7 days compared to pure PCL and SF nanofibers.en_US
dc.identifier.citationYıldız, G., Arslan, Y. E., Derkus, B., Sezgin, B., Menceloglu, Y. Z., & Bayar, G. R. (2024). Development and characterization of skin substitutes from electrospun polycaprolactone/silk fibroin. Journal of Bioactive and Compatible Polymers, 39(1), 46–62. doi: 10.1177/08839115231216998en_US
dc.identifier.doi10.1177/08839115231216998
dc.identifier.endpage62en_US
dc.identifier.issn0883-9115
dc.identifier.issn1530-8030
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85178893641
dc.identifier.startpage46en_US
dc.identifier.urihttps://doi.org/10.1177/08839115231216998
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5755
dc.identifier.volume39en_US
dc.identifier.wosWOS:001117848500001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorArslan, Yavuz Emre
dc.language.isoen
dc.publisherSAGE Publications Ltden_US
dc.relation.ispartofJournal of Bioactive and Compatible Polymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiomaterialsen_US
dc.subjectElectrospinningen_US
dc.subjectPCLen_US
dc.subjectPolymer nanofibersen_US
dc.subjectSilk fibroinen_US
dc.subjectSkin tissue engineeringen_US
dc.titleDevelopment and characterization of skin substitutes from electrospun polycaprolactone/silk fibroin
dc.typeArticle

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