Antioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase

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dc.contributor.authorGecibesler, Ibrahim H.
dc.contributor.authorDayan, Osman
dc.contributor.authorSerbetci, Zafer
dc.contributor.authorDemirtas, Ibrahim
dc.date.accessioned2025-01-27T20:14:21Z
dc.date.available2025-01-27T20:14:21Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBiological activities of organoruthenium complexes [chloro [N,N '-[(2,6-pyridinediyl-kappa N) diethylidyne] bis-[benzenamine-kappa N]] [N-[(2-pyridinyl-kappa N) methylene] benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 1), [chloro [2,2 '-(2,6-pyridinediyl-kappa N) bis [1H-benzimidazole-kappa N-3]][N-[(2-pyridinyl-kappa N) methylene] benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 2), and [chloro[2,6-di(1H-pyrazol-3-yl-kappa N-2) pyridine-kappa N] [N-[(2-pyridinyl-kappa N) methylene] [benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 3) have been studies. The compounds were tested for in vitro biological activity on test models including 2,2-diphenyl-1-picryl-hydrazyl (DPPH) reducing power, superoxide anion radical-scavenging activity, and lipid peroxidation activity by ferric thiocyanate. It is established that Cmplx 2 with benzimidazole ligand displays significant xanthine oxidase inhibitory activity (IC50 = 53.80 +/- 2.69 mu M), DPPH free radical scavenging activity (79.49 +/- 1.59), and superoxide anion radical scavenging activity (75.73 +/- 2.85%). The coordination of benzenamine and benzenesulfanoamine ligands reduces lipid peroxidation as observed in the case of Cmplx 1 (87.17 +/- 3.88%) and the higher reducing power of Cmplx 1 obtained at all concentrations. It was concluded from the test results that organoruthenium complexes showed much better antioxidant activity than expected.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [111T560]; Scientific Research Project Department of Bingol University (BUBAP) [2010 - 07]
dc.description.sponsorshipThe authors thank for financial support the Scientific and Technological Research Council of Turkey (TUBITAK; 111T560) and the Scientific Research Project Department of Bingol University (BUBAP; 2010 - 07)
dc.identifier.doi10.1007/s11094-020-02099-w
dc.identifier.endpage920
dc.identifier.issn0091-150X
dc.identifier.issn1573-9031
dc.identifier.issue10
dc.identifier.scopus2-s2.0-85078580635
dc.identifier.scopusqualityQ4
dc.identifier.startpage914
dc.identifier.urihttps://doi.org/10.1007/s11094-020-02099-w
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21059
dc.identifier.volume53
dc.identifier.wosWOS:000507361500002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofPharmaceutical Chemistry Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDPPH free radical scavenging
dc.subjectsuperoxide anion radical scavenging
dc.subjectxanthine oxidase
dc.subjectlipid peroxidation
dc.subjectreducing power
dc.subjectorganoruthenium complexes
dc.titleAntioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase
dc.typeArticle

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