Antioxidant Activity of Ruthenium(Ii) Complexes Containing Tridentate Triamines and Their Capability to Inhibit Xanthine Oxidase
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Biological activities of organoruthenium complexes [chloro [N,N '-[(2,6-pyridinediyl-kappa N) diethylidyne] bis-[benzenamine-kappa N]] [N-[(2-pyridinyl-kappa N) methylene] benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 1), [chloro [2,2 '-(2,6-pyridinediyl-kappa N) bis [1H-benzimidazole-kappa N-3]][N-[(2-pyridinyl-kappa N) methylene] benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 2), and [chloro[2,6-di(1H-pyrazol-3-yl-kappa N-2) pyridine-kappa N] [N-[(2-pyridinyl-kappa N) methylene] [benzenesulfonamide-kappa N] ruthenium(II)] chloride (Cmplx 3) have been studies. The compounds were tested for in vitro biological activity on test models including 2,2-diphenyl-1-picryl-hydrazyl (DPPH) reducing power, superoxide anion radical-scavenging activity, and lipid peroxidation activity by ferric thiocyanate. It is established that Cmplx 2 with benzimidazole ligand displays significant xanthine oxidase inhibitory activity (IC50 = 53.80 +/- 2.69 mu M), DPPH free radical scavenging activity (79.49 +/- 1.59), and superoxide anion radical scavenging activity (75.73 +/- 2.85%). The coordination of benzenamine and benzenesulfanoamine ligands reduces lipid peroxidation as observed in the case of Cmplx 1 (87.17 +/- 3.88%) and the higher reducing power of Cmplx 1 obtained at all concentrations. It was concluded from the test results that organoruthenium complexes showed much better antioxidant activity than expected.
Açıklama
Anahtar Kelimeler
DPPH free radical scavenging, superoxide anion radical scavenging, xanthine oxidase, lipid peroxidation, reducing power, organoruthenium complexes
Kaynak
Pharmaceutical Chemistry Journal
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
53
Sayı
10
