The effect of maternal polycystic ovary morphology on first-trimester maternal serum biochemical markers of aneuploidy and fetal nuchal translucency thickness

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dc.contributor.authorHacivelioglu, S.
dc.contributor.authorUysal, A.
dc.contributor.authorGungor, A. N. Cakir
dc.contributor.authorGencer, M.
dc.contributor.authorCakir, D. U.
dc.contributor.authorCosar, E.
dc.date.accessioned2025-01-27T20:49:52Z
dc.date.available2025-01-27T20:49:52Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (beta-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester. Material and Methods: A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free beta-hCG, PAPP-A, and NT thickness were measured and compared in all patients. Results: The multiples of median (MoM) levels of serum free beta-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively). Conclusion: In pregnancies with maternal PCO morphology, the presence of higher maternal serum free beta-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.
dc.identifier.endpage35
dc.identifier.issn0390-6663
dc.identifier.issue1
dc.identifier.pmid25864278
dc.identifier.scopus2-s2.0-84924548966
dc.identifier.scopusqualityQ4
dc.identifier.startpage32
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25338
dc.identifier.volume42
dc.identifier.wosWOS:000351191400006
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherImr Press
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectMaternal serum screening test
dc.subjectNuchal translucency measurement
dc.subjectPolycystic ovary syndrome
dc.subjectPregnancy-associated plasma protein-A
dc.titleThe effect of maternal polycystic ovary morphology on first-trimester maternal serum biochemical markers of aneuploidy and fetal nuchal translucency thickness
dc.typeArticle

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