The effect of maternal polycystic ovary morphology on first-trimester maternal serum biochemical markers of aneuploidy and fetal nuchal translucency thickness
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Tarih
2015
Yazarlar
Hacivelioglu, S.
Uysal, A.
Gungor, A. N. Cakir
Gencer, M.
Cakir, D. U.
Cosar, E.
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Imr Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To evaluate the effect of maternal polycystic ovary (PCO) morphology on maternal serum free beta-human chorionic gonadotropin (beta-hCG), pregnancy associated plasma protein A (PAPP-A), and nuchal translucency (NT) thickness in the first-trimester. Material and Methods: A total of 92 pregnant women in the first-trimester were included in the study. Of them, 57 had PCO morphology, and 35 women constituted the control group, with apparently normal ovaries. Maternal serum free beta-hCG, PAPP-A, and NT thickness were measured and compared in all patients. Results: The multiples of median (MoM) levels of serum free beta-hCG were significantly higher in the PCO morphology group compared to the normal ovary group (p = 0.024). However, the MoM levels of PAPP-A were similar in both groups (p = 0.947). No difference was found between the groups in terms of fasting glucose levels and NT measurements (p = 0.976 and 0.565, respectively). Conclusion: In pregnancies with maternal PCO morphology, the presence of higher maternal serum free beta-hCG levels may require correction in the calculation of risks related to first-trimester screening for chromosomal abnormalities. Larger studies are needed to confirm our preliminary data.
Açıklama
Anahtar Kelimeler
Maternal serum screening test, Nuchal translucency measurement, Polycystic ovary syndrome, Pregnancy-associated plasma protein-A
Kaynak
Clinical and Experimental Obstetrics & Gynecology
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
42
Sayı
1
