Poly(vinyl alcohol)-tannic Acid Cryogel Matrix as Antioxidant and Antibacterial Material

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dc.authoridAri, Betül / 0000-0003-3557-3055en_US
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954en_US
dc.authoridDemirci, Şahin / 0000-0001-7083-1481en_US
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530Xen_US
dc.authorscopusidAri, Betül / 57392706000en_US
dc.authorscopusidŞahiner, Mehtap / 24472372400en_US
dc.authorscopusidDemirci, Şahin / 56026625600en_US
dc.authorscopusidŞahiner, Nurettin / 6602001525en_US
dc.authorwosidDemirci, Şahin / U-5844-2019en_US
dc.authorwosidŞahiner, Nurettin / DVD-0927-2022en_US
dc.contributor.authorAri, Betül
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorDemirci, Şahin
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2023-03-27T08:05:00Z
dc.date.available2023-03-27T08:05:00Z
dc.date.issued2022en_US
dc.departmentFakülteler, Fen Fakültesi, Kimya Bölümü
dc.description.abstractThe biocompatible, viscoelastic properties of poly(vinyl alcohol) (PVA) in combination with the antimicrobial and antioxidant natural polyphenolic, tannic acid (TA), and the natural flavonoid and antioxidant curcumin (Cur), were used in the preparation of PVA:TA and PVA:TA:Cur cryogel composites using cryotropic gelation to combine the individually beneficial properties. The effect of TA content on the antioxidant and antimicrobial activities of PVA:TA cryogel composites and the antioxidant activities of PVA:TA:Cur cryogel composites was determined using Trolox equivalent antioxidant capacity (TEAC) and total phenol content (TPC) assays, and were compared. The PVA:TA:Cur cryogel composite showed the highest antioxidant activity, with a TEAC value of 2.10 ± 0.24 and a TPC value of 293 ± 12.00. The antibacterial capacity of the PVA:TA and PVA:TA:Cur 1:1:0.1 cryogel composites was examined against two different species of bacteria, E. coli and S. aureus. It was found that the minimum inhibition concentration (MIC) value of the PVA:TA:Cur 1:1:0.1 cryogel composites varied between 5 and 10 mg/mL based on the type of microorganism, and the minimum bactericidal concentration (MBC) value was 20 mg/mL irrespective of the type of microorganism. Furthermore, the hemocompatibility of the PVA:TA cryogel composites was evaluated by examining their hemolytic and coagulation behaviors. PVA:TA 1:1 cryogels with a value of 95.7% revealed the highest blood clotting index value amongst all of the synthesized cryogels, signifying the potential for blood contacting applications. The release of TA and Cur from the cryogel composites was quantified at different pH conditions, i.e., 1.0, 7.4, and 9.0, and additionally in ethanol (EtOH) and an ethanol–water (EtOH:Wat) mixture. The solution released from the PVA:TA cryogels in PBS was tested for inhibition capability against α-glucosidase (E.C. 3.2.1.20). Concentration-dependent enzyme inhibition was observed, and 70 µL of 83 µg/mL PVA:TA (1:1) cryogel in PBS inhibited α-glucosidase enzyme solution of 0.03 unit/mL in 70 µL by 81.75 ± 0.96%.en_US
dc.identifier.citationAri, B., Sahiner, M., Demirci, S., & Sahiner, N. (2022). Poly(vinyl alcohol)-tannic acid cryogel matrix as antioxidant and antibacterial material. Polymers, 14(1) doi:10.3390/polym14010070en_US
dc.identifier.doi10.3390/polym14010070
dc.identifier.issn2073-4360
dc.identifier.issue1en_US
dc.identifier.pmidPMID: 35012093
dc.identifier.scopus2-s2.0-85122063402
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym14010070
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3843
dc.identifier.volume14en_US
dc.identifier.wosWOS:000741434700001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorArı, Betül
dc.institutionauthorŞahiner, Mehtap
dc.institutionauthorDemirci, Şahin
dc.institutionauthorŞahiner, Nurettin
dc.language.isoen
dc.publisherMDPI (Multidisciplinary Digital Publishing Institute)en_US
dc.relation.ispartofPolymersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectCryogelen_US
dc.subjectAntioxidanten_US
dc.subjectAntibacterialen_US
dc.subjectPolyvinyl alcoholen_US
dc.subjectPhenolic compounden_US
dc.titlePoly(vinyl alcohol)-tannic Acid Cryogel Matrix as Antioxidant and Antibacterial Material
dc.typeArticle

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