A Schiff base colorimetric probe for real-time naked-eye detection of biologically important fluoride and cyanide ions: Single crystal, experimental, theoretical, biological and antioxidant studies

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dc.authoridZeyrek, Celal Tugrul/0000-0001-6744-7841
dc.contributor.authorUnver, Huseyin
dc.contributor.authorBoyacioglu, Bahadir
dc.contributor.authorDemir, Neslihan
dc.contributor.authorZeyrek, Celal Tugrul
dc.contributor.authorYıldız, Mustafa
dc.date.accessioned2025-01-27T20:26:51Z
dc.date.available2025-01-27T20:26:51Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThe synthesis and characterization of a Schiff base (E)-2-((3,5-bis(trifluoromethyl)phenylimino)methyl)4-methylphenol from the reaction of 2-hydroxy-5-methylbenzaldehyde with 3,5-bis(trifluoromethyl) aniline has been studied using X-ray single-crystal techniques and compared to the results from theoretical calculations using density functional theory (DFT). We have investigated the antimicrobial activities of the title compound for their minimum inhibitory concentration (MIC). We have also examined the interactions with DNA by using the UV-Visible and agarose gel electrophoresis methods. It is shown that the title compound interacts with CT-DNA via electrostatic binding. The antioxidant activity of the title compound was measured by using the DPPH method. It is furthermore shown that it indicates lower antioxidant activity than butylated hydroxytoluene (BHT). It is also found that activity remained constant with increasing compound concentration. We have also investigated the colorimetric response of the title compound in dimethyl sulfoxide (DMSO) to the addition of an equivalent amount of anions (F-, Br-, I-, CN-, SCN-, ClO4-, HSO4-, AcO-, H2PO4 and OH-). In this context, while the addition of Fand CN anions into the solution containing the title compound resulted in a significant colour change, the addition of Br-, I-, SCN-, ClO4-, HSO4-, AcO-, H2PO4 and OH anions resulted in no colour change. In the presence of these anion solutions, only Fand CN solutions underwent impressive colour change detectable with the naked eye from colourless to orange-red and purple, and orange and blue-violet in both daylight and UV light, respectively. The most discernible colour change in the Schiff base was caused by Fand CN-, which demonstrated that the Schiff base could be used to selectively detect Fand CN-. Also, various sensor applications of Schiff base were investigated. For this, the alumina oxide sheet and filter paper impregnated with the title compound were used. (C) 2020 Elsevier B.V. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [115F253]; Ankara University Coordination Unit of Scientific Research Projects [18B0504001]
dc.description.sponsorshipThe authors are grateful to the Scientific and Technological Research Council of Turkey (TUBITAK) for the financial support of this work, grant number 115F253. One of the authors (H. Unver) wishes to acknowledge gratefully the support given by Ankara University Coordination Unit of Scientific Research Projects for a research grant Project No.: 18B0504001 for carrying out this investigation.
dc.identifier.doi10.1016/j.molstruc.2020.128663
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85087525083
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2020.128663
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22457
dc.identifier.volume1221
dc.identifier.wosWOS:000598076400014
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Molecular Structure
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectX-ray analysis
dc.subjectNLO
dc.subjectDNA cleavage
dc.subjectDNA binding
dc.subjectAntioxidant
dc.subjectAnion sensors
dc.titleA Schiff base colorimetric probe for real-time naked-eye detection of biologically important fluoride and cyanide ions: Single crystal, experimental, theoretical, biological and antioxidant studies
dc.typeArticle

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