A Schiff base colorimetric probe for real-time naked-eye detection of biologically important fluoride and cyanide ions: Single crystal, experimental, theoretical, biological and antioxidant studies
[ X ]
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The synthesis and characterization of a Schiff base (E)-2-((3,5-bis(trifluoromethyl)phenylimino)methyl)4-methylphenol from the reaction of 2-hydroxy-5-methylbenzaldehyde with 3,5-bis(trifluoromethyl) aniline has been studied using X-ray single-crystal techniques and compared to the results from theoretical calculations using density functional theory (DFT). We have investigated the antimicrobial activities of the title compound for their minimum inhibitory concentration (MIC). We have also examined the interactions with DNA by using the UV-Visible and agarose gel electrophoresis methods. It is shown that the title compound interacts with CT-DNA via electrostatic binding. The antioxidant activity of the title compound was measured by using the DPPH method. It is furthermore shown that it indicates lower antioxidant activity than butylated hydroxytoluene (BHT). It is also found that activity remained constant with increasing compound concentration. We have also investigated the colorimetric response of the title compound in dimethyl sulfoxide (DMSO) to the addition of an equivalent amount of anions (F-, Br-, I-, CN-, SCN-, ClO4-, HSO4-, AcO-, H2PO4 and OH-). In this context, while the addition of Fand CN anions into the solution containing the title compound resulted in a significant colour change, the addition of Br-, I-, SCN-, ClO4-, HSO4-, AcO-, H2PO4 and OH anions resulted in no colour change. In the presence of these anion solutions, only Fand CN solutions underwent impressive colour change detectable with the naked eye from colourless to orange-red and purple, and orange and blue-violet in both daylight and UV light, respectively. The most discernible colour change in the Schiff base was caused by Fand CN-, which demonstrated that the Schiff base could be used to selectively detect Fand CN-. Also, various sensor applications of Schiff base were investigated. For this, the alumina oxide sheet and filter paper impregnated with the title compound were used. (C) 2020 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
X-ray analysis, NLO, DNA cleavage, DNA binding, Antioxidant, Anion sensors
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
1221
