Rapid Pathogen Purge by Photosensitive Arginine-Riboflavin Carbon Dots without Toxicity

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorBhethanabotla, Venkat R.
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:58:28Z
dc.date.available2025-01-27T20:58:28Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractPhoto-activatable antipathogenic carbon dots (CDs) were prepared by carbonization of citric acid and arginine (Arg) via 3 min microwave treatment for use in the eradication of common microorganisms. Nitrogen-doped Arg CDs were spherical in shape with a size range of 0.5 to 5 nm. The Arg CDs were modified with fluorescent dyes, such as fluorescein sodium salt (FSS, as Arg-FSS) and riboflavin (RBF, as Arg-RBF), to improve antimicrobial potency by enhancing their application in photodynamic therapy. The modified Arg CDs afforded fluorescence emission properties at 520 nm in the green region in addition to excellent blue fluorescence intensity at 420 nm under 345 nm excitation upon their FSS and RBF conjugation, respectively. Although the cytotoxicity of Arg CDs was decreased for Arg-RBF CDs to 91.2 +/- 0.7% cell viability for fibroblasts, the Arg-based CDs could be safely used for intravenous applications at 1000 mu g/mL concentration. The Arg CDs showed broad-spectrum antimicrobial activity against common pathogens and the minimum inhibitory concentration of Arg CDs was almost two-fold decreased for the modified forms without UV light. However, faster and more effective antibacterial activity was determined for photosensitive Arg-RBF CDs, with total bacterial eradication upon UV-A light exposure for 30 min.
dc.description.sponsorshipThe authors thank Aynur Sanem Yilmaz for support in the biocompatibility studies.
dc.description.sponsorshipThe authors thank Aynur Sanem Yilmaz for support in the biocompatibility studies.
dc.identifier.doi10.3390/ma16196512
dc.identifier.issn1996-1944
dc.identifier.issue19
dc.identifier.pmid37834647
dc.identifier.scopus2-s2.0-85174056592
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.3390/ma16196512
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26712
dc.identifier.volume16
dc.identifier.wosWOS:001081472300001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMaterials
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectdual-fluorescence carbon dots (CQ dots)
dc.subjectarginine amino acid-derived CQ dots
dc.subjectfluorescein sodium salt/riboflavin dye
dc.subjectantimicrobial
dc.subjectphotodynamic therapy
dc.subjectbiocompatible CQ dots
dc.titleRapid Pathogen Purge by Photosensitive Arginine-Riboflavin Carbon Dots without Toxicity
dc.typeArticle

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