BCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms

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dc.authoridZeng, Maomao/0000-0001-9259-1992
dc.authoridBrennan, Charles/0000-0003-2479-8478
dc.authoridProestos, Charalampos/0000-0002-3450-5969
dc.authoridYilmaz, Selin/0009-0006-4499-2250
dc.authoridKARAV, SERCAN/0000-0003-4056-1673
dc.authoridBolat, Ecem/0009-0001-7086-3317
dc.authoridOz, Fatih/0000-0002-5300-7519
dc.contributor.authorBolat, Ecem
dc.contributor.authorEker, Furkan
dc.contributor.authorYilmaz, Selin
dc.contributor.authorKarav, Sercan
dc.contributor.authorOz, Emel
dc.contributor.authorBrennan, Charles
dc.contributor.authorProestos, Charalampos
dc.date.accessioned2025-01-27T20:16:31Z
dc.date.available2025-01-27T20:16:31Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBovine milk is an essential supplement due to its rich energy- and nutrient-rich qualities. Caseins constitute the vast majority of the proteins in milk. Among these, beta-casein comprises around 37% of all caseins, and it is an important type of casein with several different variants. The A1 and A2 variants of beta-casein are the most researched genotypes due to the changes in their composition. It is accepted that the A2 variant is ancestral, while a point mutation in the 67th amino acid created the A1 variant. The digestion derived of both A1 and A2 milk is BCM-7. Digestion of A2 milk in the human intestine also forms BCM-9 peptide molecule. The opioid-like characteristics of BCM-7 are highlighted for their potential triggering effect on several diseases. Most research has been focused on gastrointestinal-related diseases; however other metabolic and nervous system-based diseases are also potentially triggered. By manipulating the mechanisms of these diseases, BCM-7 can induce certain situations, such as conformational changes, reduction in protein activity, and the creation of undesired activity in the biological system. Furthermore, the genotype of casein can also play a role in bone health, such as altering fracture rates, and calcium contents can change the characteristics of dietary products. The context between opioid molecules and BCM-7 points to a potential triggering mechanism for the central nervous system and other metabolic diseases discussed.
dc.identifier.doi10.3390/molecules29092161
dc.identifier.issn1420-3049
dc.identifier.issue9
dc.identifier.pmid38731652
dc.identifier.scopus2-s2.0-85192739476
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/molecules29092161
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21269
dc.identifier.volume29
dc.identifier.wosWOS:001220101100001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMolecules
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectbeta-casomorphin-7
dc.subjectA1 milk
dc.subjectA2 milk
dc.subjectopioid peptide
dc.subjecthealth effect
dc.titleBCM-7: Opioid-like Peptide with Potential Role in Disease Mechanisms
dc.typeReview Article

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