Synthesis and Characterization of Crown Ethers

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dc.authoridDulger, Basaran/0000-0002-3184-2652
dc.authoridKiraz, Askin/0000-0002-2350-8291
dc.contributor.authorKiraz, Askin
dc.contributor.authorYıldız, Mustafa
dc.contributor.authorDulger, Basaran
dc.date.accessioned2025-01-27T20:56:17Z
dc.date.available2025-01-27T20:56:17Z
dc.date.issued2009
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractCrown ether ligands of Schiff base type (6-17) have been synthesized by the reaction of 2-hydroxybenzaidehyde, 2-hydroxy-5-methoxybenzaldehyde 2-hydroxy-5-bromobenzaldehyde, 2-hydroxy-5-chlorobenzaldehyde, 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde with 6,7,8,14-tetrahydrodibenzo[f,i][ 1,5]dioxecine-2,12-diamine (4) and 7,9,10,16-tetrahydro-6H-dibenzo[h,k][ 1,4,7]-trioxacyclododecine-2,14-diamine (5). The structures of Schiff base crown ethers have been investigated by elemental analysis, IR, UV-visible, H-1 NMR, C-13 NMR and MS spectroscopic data. In solution, all Schiff bases exist as equilibrium mixtures of enol-imine and keto-imine tautomers. For four Schiff bases (10, 11, 16, 17). the keto-imine form has been found to be dominant in the DMSO. The antimicrobial activities of the compounds are evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) against 9 bacteria and 5 yeast. cultures. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of penicillin-G, ampicillin, cefotaxime, vancomycin, oflaxacin, tetracycline 8 antibacterial agents and nystatin, ketaconazole and clotrimazole as commercial antifungal agents. In most cases, the compounds show broad-spectrum (Grain-positive and Gram-negative bacteria) activities that are comparatively either, slightly less active or equipotent to, antimicrobial agents in the comparison tests.
dc.description.sponsorshipCanakkale Onsekiz Mart University Grants Commission [2006/07]
dc.description.sponsorshipThe authors thank Canakkale Onsekiz Mart University Grants Commission for a research grant (Project Number: 2006/07).
dc.identifier.endpage4507
dc.identifier.issn0970-7077
dc.identifier.issn0975-427X
dc.identifier.issue6
dc.identifier.scopus2-s2.0-69749091542
dc.identifier.scopusqualityQ4
dc.identifier.startpage4495
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26362
dc.identifier.volume21
dc.identifier.wosWOS:000269018100055
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAsian Journal Of Chemistry
dc.relation.ispartofAsian Journal of Chemistry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectCrown ether
dc.subjectSchiff base
dc.subjectAntimicrobial activity
dc.titleSynthesis and Characterization of Crown Ethers
dc.typeArticle

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