Synthesis and Characterization of Crown Ethers

[ X ]

Tarih

2009

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Asian Journal Of Chemistry

Erişim Hakkı

info:eu-repo/semantics/closedAccess

Özet

Crown ether ligands of Schiff base type (6-17) have been synthesized by the reaction of 2-hydroxybenzaidehyde, 2-hydroxy-5-methoxybenzaldehyde 2-hydroxy-5-bromobenzaldehyde, 2-hydroxy-5-chlorobenzaldehyde, 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde with 6,7,8,14-tetrahydrodibenzo[f,i][ 1,5]dioxecine-2,12-diamine (4) and 7,9,10,16-tetrahydro-6H-dibenzo[h,k][ 1,4,7]-trioxacyclododecine-2,14-diamine (5). The structures of Schiff base crown ethers have been investigated by elemental analysis, IR, UV-visible, H-1 NMR, C-13 NMR and MS spectroscopic data. In solution, all Schiff bases exist as equilibrium mixtures of enol-imine and keto-imine tautomers. For four Schiff bases (10, 11, 16, 17). the keto-imine form has been found to be dominant in the DMSO. The antimicrobial activities of the compounds are evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) against 9 bacteria and 5 yeast. cultures. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of penicillin-G, ampicillin, cefotaxime, vancomycin, oflaxacin, tetracycline 8 antibacterial agents and nystatin, ketaconazole and clotrimazole as commercial antifungal agents. In most cases, the compounds show broad-spectrum (Grain-positive and Gram-negative bacteria) activities that are comparatively either, slightly less active or equipotent to, antimicrobial agents in the comparison tests.

Açıklama

Anahtar Kelimeler

Crown ether, Schiff base, Antimicrobial activity

Kaynak

Asian Journal of Chemistry

WoS Q Değeri

Q4

Scopus Q Değeri

Q4

Cilt

21

Sayı

6

Künye