Synthesis and Characterization of Crown Ethers
[ X ]
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Asian Journal Of Chemistry
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Crown ether ligands of Schiff base type (6-17) have been synthesized by the reaction of 2-hydroxybenzaidehyde, 2-hydroxy-5-methoxybenzaldehyde 2-hydroxy-5-bromobenzaldehyde, 2-hydroxy-5-chlorobenzaldehyde, 2-hydroxy-5-nitrobenzaldehyde and 2-hydroxy-1-naphthaldehyde with 6,7,8,14-tetrahydrodibenzo[f,i][ 1,5]dioxecine-2,12-diamine (4) and 7,9,10,16-tetrahydro-6H-dibenzo[h,k][ 1,4,7]-trioxacyclododecine-2,14-diamine (5). The structures of Schiff base crown ethers have been investigated by elemental analysis, IR, UV-visible, H-1 NMR, C-13 NMR and MS spectroscopic data. In solution, all Schiff bases exist as equilibrium mixtures of enol-imine and keto-imine tautomers. For four Schiff bases (10, 11, 16, 17). the keto-imine form has been found to be dominant in the DMSO. The antimicrobial activities of the compounds are evaluated using disk diffusion method in dimethyl sulfoxide (DMSO) against 9 bacteria and 5 yeast. cultures. The obtained results from disk diffusion method are assessed in side-by-side comparison with those of penicillin-G, ampicillin, cefotaxime, vancomycin, oflaxacin, tetracycline 8 antibacterial agents and nystatin, ketaconazole and clotrimazole as commercial antifungal agents. In most cases, the compounds show broad-spectrum (Grain-positive and Gram-negative bacteria) activities that are comparatively either, slightly less active or equipotent to, antimicrobial agents in the comparison tests.
Açıklama
Anahtar Kelimeler
Crown ether, Schiff base, Antimicrobial activity
Kaynak
Asian Journal of Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
21
Sayı
6
