Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum

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dc.contributor.authorBeyazit, Fatma
dc.contributor.authorPek, Eren
dc.contributor.authorTurkon, Hakan
dc.date.accessioned2025-01-27T20:46:04Z
dc.date.available2025-01-27T20:46:04Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAim: Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) concentration and IMA/albumin ratio (IMAR) in HEG patients. Methods: One patient group and two control groups were constituted. Pregnant subjects with HEG were included in HEG group (n=31) and age-, gestational age-, and body mass index (BMI)-matched healthy pregnant women in control group (n=30). The second control group was constituted from age- and BMI-matched non-pregnant women (n=30). Serum IMA, IMAR blood glucose, albumin, urea, creatinine, alanine aminotransferase and aspartate aminotransferase levels were measured in all subjects. Results: Serum median IMA levels [0.55 (0.43-0.68)] was found to be elevated in HEG patients compared with pregnant [0.52 (0.34-0.61)] and non-pregnant controls [0.48 (0.27-0.57)] (p=<0.001). IMAR levels were also found to be significantly elevated in HEG patients compared to both control groups. According to correlation analysis, IMA and IMAR levels were only correlated with C-reactive protein levels. Conclusion: Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment.
dc.identifier.doi10.4274/haseki.4019
dc.identifier.endpage298
dc.identifier.issn1302-0072
dc.identifier.issn2147-2688
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85059580550
dc.identifier.scopusqualityQ3
dc.identifier.startpage292
dc.identifier.trdizinid297297
dc.identifier.urihttps://doi.org/10.4274/haseki.4019
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/297297
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24801
dc.identifier.volume56
dc.identifier.wosWOS:000454961900006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherGalenos Yayincilik
dc.relation.ispartofHaseki Tip Bulteni-Medical Bulletin of Haseki
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectHyperemesis gravidarum
dc.subjectischemia-modified albumin
dc.subjectischemia-modified albumin/albumin ratio
dc.subjectoxidative stress
dc.titleSerum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum
dc.title.alternativeHiperemezis gravidarumda serum iskemi modifiye albümin ve iskemi modifiye albümin/albümin oranının değerlendirilmesi
dc.typeArticle

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