Fabrication and Characterization of Saffron Stamen Aqueous Extract Controlled Release System as Potential Topical Treatment of Thermal Burn Wounds

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dc.authorscopusid55858603800en_US
dc.authorwosidU-4529-2018en_US
dc.contributor.authorÖzdemir, Burak
dc.contributor.authorPişkin, Mehmet Burçin
dc.contributor.authorGök, Bahar
dc.contributor.authorDemir, Neslihan
dc.contributor.authorBudama-Kılınç, Yasemin
dc.date.accessioned2025-02-07T06:11:56Z
dc.date.available2025-02-07T06:11:56Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractIn our study, we aimed the preparation of Saffron stamen aqueous extract (SSAE) loaded chitosan nanoparticles (CNPs) to be used topically for thermal burns. First, biological activity tests such as DNA binding, DNA cleavage and antibacterial activity were performed to determine the effectiveness of SSAE to be encapsulated. Additionally, a genotoxicity test was performed for the reliability of SSAE. Ionic gelation method was used for encapsulation, and SSAE-loaded CNPs were obtained. Average particle size, zeta potential, polydispersity index (PdI), morphology, and releasing kinetics of the SSAE-loaded CNPs and blank CNPs were determined. DNA binding showed that SSAE interacted with DNA electrostatically. It was determined that all doses of SSAE used in hydrolytic and oxidative DNA cleavage experiments cleave DNA. As a result of the Ames / Salmonella test, it was found that 1,25 mg SSAE was not genotoxic. Then, this concentration was used in nanoparticle synthesis. As a result of DLS analysis, it was determined that SSAE-loaded CNPs have an average size of 57.61±1.234 nm, 0.175±0.008 PdI, and +14±0.755 mV zeta potential. Encapsulation efficiency and loading capacity of SSAE-loaded CNPs calculated as 71.76 % and 2,64 % respectively. As a result of releasing kinetics, it was determined that 79.54 % of SSAE was released after 168 hours. Antibacterial results revealed that SSAE loaded CNPs were more effective against bacteria than blank SSAE.en_US
dc.identifier.citationÖzdemir, B., Pişkin, M. B., Gök, B., Demir, N., & Budama-Kılınç, Y. (2021). Fabrication and Characterization of Saffron Stamen Aqueous Extract Controlled Release System as Potential Topical Treatment of Thermal Burn Wounds. ChemistrySelect, 6(25), 6579–6585. https://doi.org/10.1002/slct.202101413en_US
dc.identifier.doi10.1002/slct.202101413en_US
dc.identifier.endpage6585en_US
dc.identifier.issn2365-6549
dc.identifier.issue25en_US
dc.identifier.scopus2-s2.0-85110520757en_US
dc.identifier.scopusqualityQ3
dc.identifier.startpage6579en_US
dc.identifier.urihttps://doi.org/10.1002/slct.202101413
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29570
dc.identifier.volume6en_US
dc.identifier.wosWOS:000674289000028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorDemir, Neslihan
dc.language.isoengen_US
dc.publisherJohn Wiley and Sons Incen_US
dc.relation.ispartofChemistrySelecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterialen_US
dc.subjectChitosanen_US
dc.subjectControlled Release Systemen_US
dc.subjectDNA Bindingen_US
dc.subjectDNA Cleavageen_US
dc.subjectSaffronen_US
dc.titleFabrication and Characterization of Saffron Stamen Aqueous Extract Controlled Release System as Potential Topical Treatment of Thermal Burn Woundsen_US
dc.typearticleen_US

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