Glucosinolates in Human Health: Metabolic Pathways, Bioavailability, and Potential in Chronic Disease Prevention

Basit Öğe Kaydı
dc.authoridKarav, Sercan / 0000-0003-4056-1673
dc.contributor.authorBaldelli, Sara
dc.contributor.authorLombardo, Mauro
dc.contributor.authorD'Amato, Alfonsina
dc.contributor.authorKarav, Sercan
dc.contributor.authorTripodi, Gianluca
dc.contributor.authorAiello, Gilda
dc.date.accessioned2025-05-29T02:57:23Z
dc.date.available2025-05-29T02:57:23Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractGlucosinolates (GSLs) are sulfur-containing compounds predominantly found in cruciferous vegetables such as broccoli, kale, and Brussels sprouts, and are recognized for their health-promoting properties. Upon consumption, GSLs undergo hydrolysis by the enzyme myrosinase, resulting in bioactive compounds like isothiocyanates and specific indole glucosinolate degradation products, such as indole-3-carbinol (I3C) and 3,3 '-diindolylmethane (DIM), which contribute to a range of health benefits, including anti-cancer, anti-inflammatory, and cardioprotective effects. This review explores the structure, metabolism, and bioavailability of GSLs. Recent evidence supports the protective role of GSLs in chronic diseases, with mechanisms including the modulation of oxidative stress, inflammation, and detoxification pathways. Furthermore, the innovative strategies to enhance GSL bioactivity, such as biofortification, genetic introgression, and optimized food processing methods, have been examined. These approaches seek to increase GSL content in edible plants, thereby maximizing their health benefits. This comprehensive review provides insights into dietary recommendations, the impact of food preparation, and recent advances in GSL bioavailability enhancement, highlighting the significant potential of these bioactive compounds in promoting human health and preventing chronic diseases.
dc.identifier.doi10.3390/foods14060912
dc.identifier.issn2304-8158
dc.identifier.issue6
dc.identifier.pmid40231924
dc.identifier.scopus2-s2.0-105001242467
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/foods14060912
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30042
dc.identifier.volume14
dc.identifier.wosWOS:001452418900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMDPI
dc.relation.ispartofFoods
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250529
dc.subjectcruciferous vegetables
dc.subjectnutrition
dc.subjectbioactive compounds
dc.subjectglucosinolates
dc.titleGlucosinolates in Human Health: Metabolic Pathways, Bioavailability, and Potential in Chronic Disease Prevention
dc.typeReview

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Sercan Karav_Review.pdf
Boyut:
3.31 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Moleküler Biyoloji ve Genetik Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu