A Comprehensive Diagnostic Assessment of Thyroid Nodules Utilizing Scintigraphy and Telomere Lengths (T/S ratios)

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dc.authorid0000-0003-3590-2656
dc.contributor.authorOzturk, Fulya Koc
dc.contributor.authorOzdemir, Semra Usta
dc.contributor.authorKarakilic, Ersen
dc.contributor.authorSilan, Fatma
dc.date.accessioned2026-02-03T11:59:44Z
dc.date.available2026-02-03T11:59:44Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: This study aims to evaluate the effectiveness and role of telomere length measurements in leukocytes, plasma free cell DNA (cfDNA), and biopsy cells, along with technetium-99m (Tc-99m) methoxyisobutylisonitrile (MIBI) scintigraphy, as non-invasive methods for diagnosing malignant thyroid lesions. Methods: Data from 128 patients, who underwent ultrasound, Tc-99m MIBI scintigraphy, and fine-needle biopsy with a preliminary diagnosis of malignant thyroid nodules, were analyzed. In 98 patients, telomere lengths in leukocytes (from blood), cfDNA (from plasma), and biopsy cells were measured using the quantitative polymerase chain reaction method, and the relative telomere/single copy gene (T/S) ratio was calculated. Based on cytological examination results, patients were categorized into three groups: malignant, benign, and suspicious. Group differences were analyzed using the Kruskal-Wallis and Chi-square tests, and correlations between variables were examined with Spearman correlation analysis. Results: The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of Tc-99m MIBI scintigraphy for diagnosing malignant thyroid nodules were 64.70%, 79.16%, 29.72%, 83.51%, and 67.96%, respectively. While these results align with the literature, the positive predictive value was notably lower. No significant differences were observed in telomere lengths (T/S ratios) in leukocytes, plasma, or tissue between the groups. Conclusion: Tc-99m MIBI scintigraphy demonstrates reasonable diagnostic accuracy for identifying malignancy in thyroid nodules. Contrary to limited reports, telomere length measurements may not be a reliable method for predicting thyroid malignancy. Larger studies are needed to further explore these findings.
dc.identifier.doi10.4274/mirt.galenos.2025.85429
dc.identifier.endpage106
dc.identifier.issn2146-1414
dc.identifier.issn2147-1959
dc.identifier.issue2
dc.identifier.pmid40458946
dc.identifier.scopus2-s2.0-105007978214
dc.identifier.scopusqualityQ3
dc.identifier.startpage97
dc.identifier.trdizinid1326699
dc.identifier.urihttps://doi.org/10.4274/mirt.galenos.2025.85429
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1326699
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34398
dc.identifier.volume34
dc.identifier.wosWOS:001506858700001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofMolecular Imaging and Radionuclide Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectThyroid cancer
dc.subjecttechnetium-99m methoxyisobutylisonitrile scintigraphy
dc.subjectcell DNA
dc.subjectliquid biopsy
dc.subjectcirculating tumor DNA
dc.subjecttelomere
dc.titleA Comprehensive Diagnostic Assessment of Thyroid Nodules Utilizing Scintigraphy and Telomere Lengths (T/S ratios)
dc.typeArticle

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