The Potential Therapeutic Effects of Agmatine, Methylprednisolone, and Rapamycin on Experimental Spinal Cord Injury

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dc.authorid0000-0003-0344-6246en_US
dc.authorscopusid57191676140en_US
dc.authorwosid-en_US
dc.contributor.authorFırat, Tülin
dc.contributor.authorKukner, Aysel
dc.contributor.authorAytürk, Nilüfer
dc.contributor.authorGezici, Ali Rıza
dc.contributor.authorSerin, Erdinç
dc.contributor.authorÖzoğul, Candan
dc.contributor.authorTore, Fatma
dc.date.accessioned2023-07-24T12:42:47Z
dc.date.available2023-07-24T12:42:47Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractObjective: In spinal cord injury (SCI), the primary mechanical damage leads to a neuroinflammatory response and the secondary neuronal injury occurs in response to the release of reactive oxygen species (ROS). In addition to the suppression of inflammation, autophagy plays a significant role in the survival of neurons during secondary SCI. The present study aimed to examine the anti-inflammatory and autophagic effects of agmatine and rapamycin in SCI and to compare the results with methylprednisolone (MP) used in the clinic. Materials and Methods: In this animal-based experimental study, thirty adult male Sprague-Dawley rats were randomly divided into five groups as sham-control, injury, injury+MP, injury+rapamycin, injury+agmatine groups. SCI was induced by compressing the T7-8-9 segments of the spinal cord, using an aneurysm clip for one minute, and then rats were treated daily for 7 days. Seven days post-treatment, damaged spinal cord tissues of sacrificed rats were collected for microscopic and biochemical examinations using histopathologic and transmission electron microscope (TEM) scores. Malondialdehyde (MDA) and glutathione peroxidase (GPx) levels were spectrophotometrically measured. Results: The results of this study showed that the damaged area was smaller in the rapamycin group when compared to the MP group. Many autophagic vacuoles and macrophages were observed in the rapamycin group. Degeneration of axon, myelin, and wide edema was observed in SCI by electron microscopic observations. Fragmented myelin lamellae and contracted axons were also noted. While MDA and GPx levels were increased in the injury group, MDA levels were significantly decreased in the agmatine and MP groups, and GPx levels were decreased in the rapamycin group. Conclusion: The results of our study confirmed that rapamycin and agmatine can be an effective treatment for secondary injury of SCI.en_US
dc.identifier.citationFırat, T., Kukner, A., Aytürk, N., Gezici, A. R., Serin, E., Özoğul, C., & Tore, F. (2021). The potential therapeutic effects of agmatine, methylprednisolone, and rapamycin on experimental spinal cord injury. Cell Journal, 23(6), 701-707. doi:10.22074/cellj.2021.7198en_US
dc.identifier.doi10.22074/cellj.2021.7198
dc.identifier.endpage707en_US
dc.identifier.issn2228-5806
dc.identifier.issn2228-5814
dc.identifier.issue6en_US
dc.identifier.pmid34939764
dc.identifier.scopus2-s2.0-85121049317
dc.identifier.startpage701en_US
dc.identifier.urihttps://doi.org/10.22074/cellj.2021.7198
dc.identifier.urihttps://hdl.handle.net/20.500.12428/4440
dc.identifier.volume23en_US
dc.identifier.wosWOS:000728393500013
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAytürk, Nilufer
dc.language.isoen
dc.publisherRoyan Institute (ACECR)en_US
dc.relation.ispartofCell Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.subjectAgmatineen_US
dc.subjectMethylprednisoloneen_US
dc.subjectRapamycinen_US
dc.subjectSpinal Cord Injuryen_US
dc.titleThe Potential Therapeutic Effects of Agmatine, Methylprednisolone, and Rapamycin on Experimental Spinal Cord Injury
dc.typeArticle

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