Role of milk glycome in prevention, treatment, and recovery of COVID-19

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Tarih

2022

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Frontiers Media Sa

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Milk contains all essential macro and micro-nutrients for the development of the newborn. Its high therapeutic and antimicrobial content provides an important function for the prevention, treatment, and recovery of certain diseases throughout life. The bioactive components found in milk are mostly decorated with glycans, which provide proper formation and modulate the biological functions of glycosylated compounds. The glycome of milk consists of free glycans, glycolipids, and N- and O- glycosylated proteins. Recent studies have shown that both free glycans and glycan-containing molecules have antiviral characteristics based on different mechanisms such as signaling, microbiome modulation, natural decoy strategy, and immunomodulatory action. In this review, we discuss the recent clinical studies and potential mechanisms of free and conjugated glycans' role in the prevention, treatment, and recovery of COVID-19.

Açıklama

Anahtar Kelimeler

glycosylation, human milk oligosaccharides, glycans, whey protein, COVID-19, SARS-CoV-2, antiviral activity

Kaynak

Frontiers in Nutrition

WoS Q Değeri

Q2

Scopus Q Değeri

Q2

Cilt

9

Sayı

Künye