Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities

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dc.authoridKARABIYIK, HASAN/0000-0001-7894-6646
dc.authoridDogan, Ozdemir/0000-0003-3724-8942
dc.contributor.authorDogan, Ozdemir
dc.contributor.authorCakir, Sidika Polat
dc.contributor.authorBeksultanova, Nurzhan
dc.contributor.authorAltanlar, Nurten
dc.contributor.authorSimsek, Duygu
dc.contributor.authorKarabiyik, Hasan
dc.date.accessioned2025-01-27T20:49:46Z
dc.date.available2025-01-27T20:49:46Z
dc.date.issued2017
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity. (C) 2017 Elsevier Ltd. All rights reserved.
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114Z161]; Middle East Technical University (METU)
dc.description.sponsorshipWe thank the Scientific and Technological Research Council of Turkey (TUBITAK, Grant No. 114Z161) and Middle East Technical University (METU) for the financial support.
dc.identifier.doi10.1016/j.tetasy.2017.01.003
dc.identifier.endpage329
dc.identifier.issn0957-4166
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85009742525
dc.identifier.scopusqualityN/A
dc.identifier.startpage324
dc.identifier.urihttps://doi.org/10.1016/j.tetasy.2017.01.003
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25307
dc.identifier.volume28
dc.identifier.wosWOS:000395216200013
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofTetrahedron-Asymmetry
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectOxide Aziridinyl Phosphonate
dc.subjectPhosphine Oxide
dc.subjectLithiation
dc.subjectEfficient
dc.subjectArylaziridines
dc.subject2-Phosphonates
dc.subjectMiraziridine
dc.subjectDerivatives
dc.subjectAlcohols
dc.subjectNitrogen
dc.titleEnantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities
dc.typeArticle

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