Enantioselective synthesis of new chiral 2-aziridinyl phosphonates and studies of their biological activities
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Tarih
2017
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
A new series of chiral aziridinyl phosphonates has been synthesized and evaluated for antibacterial and antifungal activities. For the synthesis, a Gabriel-Cromwell reaction was used to form aziridinyl phosphonates in 52-83% yield. In order to evaluate antibacterial and antifungal activities, MIC values were measured. Although most of the compounds showed insignificant activity, two of them provided low to moderate antifungal activity. (C) 2017 Elsevier Ltd. All rights reserved.
Açıklama
Anahtar Kelimeler
Oxide Aziridinyl Phosphonate, Phosphine Oxide, Lithiation, Efficient, Arylaziridines, 2-Phosphonates, Miraziridine, Derivatives, Alcohols, Nitrogen
Kaynak
Tetrahedron-Asymmetry
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
28
Sayı
2
