Exploring the antioxidant properties of semaglutide: A comprehensive review
| dc.contributor.author | Yaribeygi, Habib | |
| dc.contributor.author | Maleki, Mina | |
| dc.contributor.author | Forouzanmehr, Behina | |
| dc.contributor.author | Kesharwani, Prashant | |
| dc.contributor.author | Jamialahmadi, Tannaz | |
| dc.contributor.author | Karav, Sercan | |
| dc.contributor.author | Sahebkar, Amirhossein | |
| dc.date.accessioned | 2025-01-27T20:49:41Z | |
| dc.date.available | 2025-01-27T20:49:41Z | |
| dc.date.issued | 2024 | |
| dc.department | Çanakkale Onsekiz Mart Üniversitesi | |
| dc.description.abstract | Patients with diabetes commonly experience an aberrant production of free radicals and weakened antioxidative defenses, making them highly susceptible to oxidative stress development. This, in turn, can induce and promote diabetic complications. Therefore, utilizing antidiabetic agents with antioxidative properties can offer dual benefits by addressing hyperglycemia and reducing oxidative damage. Semaglutide, a recently approved oral form of glucagon-like peptide-1 (GLP-1) analogues, has shown potent antidiabetic effects. Additionally, recent studies have suggested that it possesses antioxidative properties. However, the exact effects and the molecular pathways involved are not well understood. In this review, we present the latest findings on the antioxidative impacts of semaglutide and draw conclusions about the mechanisms involved. | |
| dc.identifier.doi | 10.1016/j.jdiacomp.2024.108906 | |
| dc.identifier.issn | 1056-8727 | |
| dc.identifier.issn | 1873-460X | |
| dc.identifier.issue | 12 | |
| dc.identifier.pmid | 39549371 | |
| dc.identifier.scopus | 2-s2.0-85209154825 | |
| dc.identifier.scopusquality | Q2 | |
| dc.identifier.uri | https://doi.org/10.1016/j.jdiacomp.2024.108906 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12428/25280 | |
| dc.identifier.volume | 38 | |
| dc.identifier.wos | WOS:001359879000001 | |
| dc.identifier.wosquality | N/A | |
| dc.indekslendigikaynak | Web of Science | |
| dc.indekslendigikaynak | Scopus | |
| dc.indekslendigikaynak | PubMed | |
| dc.language.iso | en | |
| dc.publisher | Elsevier Science Inc | |
| dc.relation.ispartof | Journal of Diabetes and Its Complications | |
| dc.relation.publicationcategory | info:eu-repo/semantics/openAccess | |
| dc.rights | info:eu-repo/semantics/closedAccess | |
| dc.snmz | KA_WoS_20250125 | |
| dc.subject | GLP-1 agonist | |
| dc.subject | Semaglutide | |
| dc.subject | Diabetes mellitus | |
| dc.subject | Oxidative stress | |
| dc.subject | NRF2 | |
| dc.title | Exploring the antioxidant properties of semaglutide: A comprehensive review | |
| dc.type | Review Article |
