The effect of medical ozone on oxidative stress and neuroinflammation in the early stage after experimental status epilepticus
Yükleniyor...
Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Preservation of the brain is important to reducing recurrent seizures and other neurological sequelae after status epilepticus (SE).
Medical ozone (MedO3) shows antioxidant, anti-inflammatory and anti-apoptotic properties in the human body. In this study, it
was aimed to understand the neuroprotective potential of MedO3 in the acute period after SE. Mature rats of Wistar Albino were
used for the study. Group design O3 + SE: SE induced after MedO3, O3: MedO3 alone was given, SE: SE only induced, SE +
O3; MedO3 given after SE, C: control and S: sham control group. SE was induced with lithium-pilocarpine experimental model
and evaluated on the Racine scale. Peripheral blood samples and brain tissue samples were taken before decapitation.
Histopathological evaluation of the hippocampus of the rats given medical O3 before and after SE were studied. The highest
peripheral blood oxidative stress index (OSI) was found in SE group. The OSI level in O3 + SE and SE + O3 was significantly
higher than SE/C/S. Gene expressions of TNF-α and IL-1β mRNA were significantly higher in SE compared to other groups.
Histopathologically; eosinophilia, cellular shrinkage and interstitial oedema were detected in the most severe SE and to a lesser
extent in O3 + SE/ SE + O3. MedO3 reduced SE-induced oxidative damage, neuroinflammation and neuronal injury and
contributed positively to neuroprotection.
Açıklama
Anahtar Kelimeler
Status Epilepticus, Ozone, Pilocarpine, Lithium, Rats, Neuroprotection
Kaynak
Biologia
WoS Q Değeri
Q3
Scopus Q Değeri
Cilt
76
Sayı
12
Künye
Cokyaman, T., Oztopuz, O., Coskun, O., Buyuk, B., Kiraz, H. A., & Elmas, S. (2021). The effect of medical ozone on oxidative stress and neuroinflammation in the early stage after experimental status epilepticus. Biologia, 76(12), 3875–3882. https://doi.org/10.1007/s11756-021-00911-w
