3D Bioprinting Strategies for Melatonin-Loaded Polymers in Bone Tissue Engineering

Basit Öğe Kaydı
dc.contributor.authorAykora, Damla
dc.contributor.authorOral, Ayhan
dc.contributor.authorAydeger, Cemre
dc.contributor.authorUzun, Metehan
dc.date.accessioned2025-01-27T20:56:10Z
dc.date.available2025-01-27T20:56:10Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBone pathologies are still among the most challenging issues for orthopedics. Over the past decade, different methods are developed for bone repair. In addition to advanced surgical and graft techniques, polymer-based biomaterials, bioactive glass, chitosan, hydrogels, nanoparticles, and cell-derived exosomes are used for bone healing strategies. Owing to their variation and promising advantages, most of these methods are not translated into clinical practice. Three dimensonal (3D) bioprinting is an additive manufacturing technique that has become a next-generation biomaterial technique adapted for anatomic modeling, artificial tissue or organs, grafting, and bridging tissues. Polymer-based biomaterials are mostly used for the controlled release of various drugs, therapeutic agents, mesenchymal stem cells, ions, and growth factors. Polymers are now among the most preferable materials for 3D bioprinting. Melatonin is a well-known antioxidant with many osteoinductive properties and is one of the key hormones in the brain-bone axis. 3D bioprinted melatonin-loaded polymers with unique lipophilic, anti-inflammatory, antioxidant, and osteoinductive properties for filling large bone gaps following fractures or congenital bone deformities may be developed in the future. This study summarized the benefits of 3D bioprinted and polymeric materials integrated with melatonin for sustained release in bone regeneration approaches.
dc.description.sponsorshipOpen access funding provided by Scientific and Technological Research Council of Trkiye (TBIdot;TAK).
dc.description.sponsorshipThis work requires no ethical approval or patient consent. This work received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.
dc.identifier.doi10.1002/mame.202400263
dc.identifier.issn1438-7492
dc.identifier.issn1439-2054
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85207627708
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/mame.202400263
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26328
dc.identifier.volume310
dc.identifier.wosWOS:001344922300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley-V C H Verlag Gmbh
dc.relation.ispartofMacromolecular Materials and Engineering
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subject3D bioprinting
dc.subjectbone diseases
dc.subjectbone regeneration
dc.subjectbone tissue engineering
dc.subjectmelatonin
dc.subjectpolymers
dc.title3D Bioprinting Strategies for Melatonin-Loaded Polymers in Bone Tissue Engineering
dc.typeReview Article

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu