Uridine and uridine nucleotides as novel regulators of NUCB2/nesfatin-1 neuron activation: an immunohistochemical study

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dc.authorid0000-0002-6097-5585
dc.contributor.authorHasanoglu Akbulut, N.
dc.contributor.authorTopal, G.
dc.contributor.authorKoc, C.
dc.contributor.authorCoskan, N.
dc.contributor.authorSalman, B.
dc.contributor.authorCansev, M.
dc.contributor.authorEyigor, O.
dc.date.accessioned2026-02-03T12:03:05Z
dc.date.available2026-02-03T12:03:05Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNesfatin-1, identified as an anorexigenic neuropeptide in the hypothalamus, is activated by glutamatergic agonists and innervated by excitatory and inhibitory neurons. The uridine nucleotide uridine diphosphate was recently identified as a novel regulator of feeding-related neurons. However, the activating effects of uridine and uridine nucleotides on anorexigenic NUCB2/nesfatin-1 neurons are unknown. In this study, the activating effects of intracerebroventricularly administered uridine or uridine nucleotides (UMP, UDP, UTP) on NUCB2/nesfatin-1 neurons localized in the supraoptic (SON), paraventricular (PVN), and periventricular (PeV) nuclei were determined using c-Fos immunohistochemistry. Results were evaluated as the percentage of the ratio of c-Fos-expressing (activated) NUCB2/nesfatin-1 neurons to all NUCB2/nesfatin-1 neurons. It was determined that centrally administered uridine, UMP, and UTP activated a statistically significant number of NUCB2/nesfatin-1 neurons in the SON, PVN, and PeV, compared with the saline group (p < 0.05). At the same time, the slight increase in the neuronal activation seen following UDP application was not found to be significant. The results of this study show that NUCB2/nesfatin-1 neurons respond to uridine and uridine nucleotides in the form of neuronal activation, possibly through pyrimidinergic neurotransmission.
dc.description.sponsorshipScientific Research Projects Foundation of the Bursa Uludag University [TOA-2021-684]
dc.description.sponsorshipScientific Research Projects Foundation of the Bursa Uludag University, Bursa, Turkey
dc.description.sponsorshipThis research was supported by a grant from the Scientific Research Projects Foundation of the Bursa Uludag University, Bursa, Turkey (grant no. TOA-2021-684)
dc.identifier.doi10.1007/s00418-025-02404-2
dc.identifier.issn0948-6143
dc.identifier.issn1432-119X
dc.identifier.issue1
dc.identifier.pmid40624270
dc.identifier.scopus2-s2.0-105010181141
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s00418-025-02404-2
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34968
dc.identifier.volume163
dc.identifier.wosWOS:001525691500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofHistochemistry and Cell Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260130
dc.subjectUridine
dc.subjectUridine nucleotides
dc.subjectNUCB2
dc.subjectNesfatin-1
dc.subjectNeuronal activation
dc.subjectHypothalamic nuclei
dc.titleUridine and uridine nucleotides as novel regulators of NUCB2/nesfatin-1 neuron activation: an immunohistochemical study
dc.typeArticle

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