Bovine colostrum and its potential contributions for treatment and prevention of COVID-19

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dc.authoridKARAV, SERCAN/0000-0003-4056-1673
dc.contributor.authorDuman, Hatice
dc.contributor.authorKarav, Sercan
dc.date.accessioned2025-01-27T20:34:55Z
dc.date.available2025-01-27T20:34:55Z
dc.date.issued2023
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBovine colostrum (BC) is the initial milk an animal produces after giving birth, particularly in the first few days. Numerous bioactive substances found in BC, including proteins, enzymes, growth factors, immunoglobulins, etc., are beneficial to human health. BC has a significant role to play as part of a healthy diet, with well-documented health and nutritional advantages for people. Therefore, the use of BC and its crucial derivatives in the development of functional food and pharmaceuticals for the prevention of several diseases such as gastrointestinal and respiratory system disorders is becoming increasingly popular around the world. A novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of a cluster of pneumonia cases that is called Coronavirus Disease 2019 (COVID-19) in China. After the first SARS-CoV-2 virus-related fatality was announced, the illness quickly spread throughout China and to other continents, causing a pandemic. Since then, numerous studies have been initiated to develop safe and efficient treatments. To prevent viral infection and potential lingering effects, it is important to investigate alternative treatments for COVID-19. Due to its effective bioactive profile and its immunomodulatory roles in biological processes, BC might be considered a promising approach to assist in combating people affected by the SARS-CoV-2 or prevention from the virus. BC has immunomodulatory effects because to its high concentration of bioactive components such as immunoglobulins, lactoferrin, cytokines, and growth factors, etc., which might help control immunological responses, potentially fostering a balanced immune response. Furthermore, its bioactive components have a potential cross-reactivity against SARS-CoV-2, aiding in virus neutralization and its comprehensive food profile also supplies important vitamins, minerals, and amino acids, fostering a healthy immune system. Hence, the possible contributions of BC to the management of COVID-19 were reviewed in this article based on the most recent research on the subject. Additionally, the key BC components that influence immune system modulation were evaluated. These components may serve as potential mediators or therapeutic advantages in COVID-19.
dc.description.sponsorshipTUBITAK [118z146]; Uluova Suet Ticaret A.S. (Uluova Milk Trading Co.); Elit Cikolata ve Sekerleme A.S. (Elit Chocolate and Confectionery)
dc.description.sponsorshipThe authors declare that this study received funding from TUBITAK #118z146, Uluova Sut Ticaret A.S. (Uluova Milk Trading Co.), and Elit Cikolata ve Sekerleme A.S. (Elit Chocolate and Confectionery). The funders were not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication.
dc.identifier.doi10.3389/fimmu.2023.1214514
dc.identifier.issn1664-3224
dc.identifier.pmid37908368
dc.identifier.scopus2-s2.0-85175377487
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3389/fimmu.2023.1214514
dc.identifier.urihttps://hdl.handle.net/20.500.12428/23513
dc.identifier.volume14
dc.identifier.wosWOS:001095582400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers in Immunology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectbovine colostrum
dc.subjectbioactive compound
dc.subjectimmunomodulation
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectantiviral activity
dc.subjecthealth benefits
dc.titleBovine colostrum and its potential contributions for treatment and prevention of COVID-19
dc.typeReview Article

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