G protein ?3 subunit gene polymorphism in Turkish hypertensives

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dc.authoridTURK, UGUR ONSEL/0000-0001-6348-6616
dc.authoridYildiz, Ahmet/0000-0001-9477-0740
dc.authoridErcan, Ertugrul/0000-0003-0480-4738
dc.contributor.authorAlioglu, Emin
dc.contributor.authorErcan, Ertugrul
dc.contributor.authorTengiz, Istemihan
dc.contributor.authorYildiz, Ahmet
dc.contributor.authorTuerk, Ugur Oensel
dc.contributor.authorSaygi, Serkan
dc.contributor.authorCam, F. Sirri
dc.date.accessioned2025-01-27T20:17:05Z
dc.date.available2025-01-27T20:17:05Z
dc.date.issued2008
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein (33 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein beta 3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein 133 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein 133 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (chi(2)=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein (33 subunit C825T gene polymorphism is associated with systolic and diastolic blood pressure. Furthermore, the study indicates that the G protein 133 subunit may be a susceptible gene to essential hypertension. (Anadolu Kardiyol Derg 2008; 8: 337-5)
dc.identifier.endpage335
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue5
dc.identifier.pmid18849222
dc.identifier.scopus2-s2.0-56049107893
dc.identifier.scopusqualityN/A
dc.identifier.startpage331
dc.identifier.trdizinid85749
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/85749
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21485
dc.identifier.volume8
dc.identifier.wosWOS:000260383300003
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectHypertension
dc.subjectG protein
dc.subjectgene
dc.subjectpolymorphism
dc.subjectgenetics
dc.subjectpredictive models
dc.subjectlogistic regression analysis
dc.titleG protein ?3 subunit gene polymorphism in Turkish hypertensives
dc.typeArticle

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