Melatonin ameliorates cardiac remodelling in fructose?induced metabolic syndrome rat model by using genes encoding cardiac potassium ion channels

Basit Öğe Kaydı
dc.authorid0000-0002-3672-871Xen_US
dc.authorid0000-0002-1373-6311en_US
dc.authorscopusid55897728300en_US
dc.authorscopusid57194872315en_US
dc.authorwosid-en_US
dc.authorwosid-en_US
dc.contributor.authorOvalı, Mehmet Akif
dc.contributor.authorÖztopuz, Özlem
dc.contributor.authorVardar, Selma Arzu
dc.date.accessioned2022-08-04T13:01:59Z
dc.date.available2022-08-04T13:01:59Z
dc.date.issued2021en_US
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü
dc.description.abstractBackground Metabolic syndrome comprises a group of disorders, including cardiac abnormalities. Ventricular arrhythmias observed in metabolic syndrome are due to the impaired ventricular repolarization. This study aims to determine the efects of melatonin on cardiac ventricular repolarization in metabolic syndrome rat model. Methods and results Sprague–Dawley rats were divided into control (n=8), melatonin (n=8), metabolic syndrome (n=8) and metabolic syndrome+melatonin (n=8) groups. Fructose (200 g/lt/day) was added into the drinking water during 8 weeks of rats to induce metabolic syndrome model. In the last two weeks, melatonin (20 mg/kg/day) was administered via oral gavage. Blood pressure measurements and ECG recordings were taken at three diferent times. Blood and left ventricular tissue samples were harvested and the KCNQ1,3 and KCNH2 gene expressions were analysed by qRT-PCR method. We observed insulin resistance, hyperglycemia, dyslipidemia and higher systolic blood pressure in metabolic syndrome group (p<0.01, for all). Prolonged QT interval was observed in metabolic syndrome group (p<0.001). The expression levels of the KCNQ genes encoding the Kv7 channel was signifcantly reduced, however KCNH2 gene which encodes Kv11.1 channel was increased in metabolic syndrome group compared to control group (p<0.05, p<0.001, respectively). Melatonin signifcantly normalised the prolongation on QT interval in metabolic syndrome group (p<0.001) and the expressions of the KCNQ (p<0.002) and KCNH2 genes (p=0.003). Conclusions The present study revealed that melatonin had ameliorative efects on ventricular repolarization by improving the prolonged QT duration in rats with metabolic syndrome and this efect was generated by the KCNQ and KCNH2 gene families.en_US
dc.identifier.citationOvali, M. A., Oztopuz, O., & Vardar, S. A. (2021). Melatonin ameliorates cardiac remodelling in fructose-induced metabolic syndrome rat model by using genes encoding cardiac potassium ion channels. Molecular Biology Reports, 48(8), 5811–5819. https://doi.org/10.1007/s11033-021-06526-3en_US
dc.identifier.doi10.1007/s11033-021-06526-3
dc.identifier.endpage5819en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue8en_US
dc.identifier.pmid34347240
dc.identifier.scopus2-s2.0-85111723569
dc.identifier.startpage5811en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-021-06526-3
dc.identifier.urihttps://hdl.handle.net/20.500.12428/3646
dc.identifier.volume48en_US
dc.identifier.wosWOS:000681163800003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorOvalı, Mehmet Akif
dc.institutionauthorÖztopuz, Özlem
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMelatoninen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectFructoseen_US
dc.subjectCardiac Ions Channelsen_US
dc.subjectQTcen_US
dc.titleMelatonin ameliorates cardiac remodelling in fructose?induced metabolic syndrome rat model by using genes encoding cardiac potassium ion channels
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Mehmet Akif_Ovali_Makale.pdf
Boyut:
725.21 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Araştırma Makalesi
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Temel Tıp Bilimleri Bölümü Koleksiyonu