Polyelectrolyte Chondroitin Sulfate Microgels as a Carrier Material for Rosmarinic Acid and Their Antioxidant Ability

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dc.authoridSagbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridYılmaz, Aynur Sanem / 0000-0002-5260-7678
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorSuner, Selin S.
dc.contributor.authorYılmaz, Aynur S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:22:48Z
dc.date.available2025-01-27T20:22:48Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.descriptionThis article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.description.abstractPolyelectrolyte microgels derived from natural sources such as chondroitin sulfate (CS) possess considerable interest as therapeutic carriers because of their ionic nature and controllable degradation capability in line with the extent of the used crosslinker for long-term drug delivery applications. In this study, chemically crosslinked CS microgels were synthesized in a single step and treated with an ammonia solution to attain polyelectrolyte CS-[NH4](+) microgels via a cation exchange reaction. The spherical and non-porous CS microgels were injectable and in the size range of a few hundred nanometers to tens of micrometers. The average size distribution of the CS microgels and their polyelectrolyte forms were not significantly affected by medium pH. It was determined that the -34 +/- 4 mV zeta potential of the CS microgels was changed to -23 +/- 3 mV for CS- [NH4](+) microgels with pH 7 medium. No important toxicity was determined on L929 fibroblast cells, with 76 +/- 1% viability in the presence of 1000 mu g/mL concentration of CS-[NH4](+) microgels. Furthermore, these microgels were used as a drug carrier material for rosmarinic acid (RA) active agent. The RA-loading capacity was about 2.5-fold increased for CS-[R](+) microgels with 32.4 +/- 5.1 mu g/mg RA loading, and 23% of the loaded RA was sustainably release for a long-term period within 150 h in comparison to CS microgels. Moreover, RA-loaded CS-[R](+) microgels exhibited great antioxidant activity, with 0.45 +/- 0.02 mu mol/g Trolox equivalent antioxidant capacity in comparison to no antioxidant properties for bare CS particles.
dc.identifier.doi10.3390/polym14204324
dc.identifier.issn2073-4360
dc.identifier.issue20
dc.identifier.pmid36297903
dc.identifier.scopus2-s2.0-85140777192
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym14204324
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22035
dc.identifier.volume14
dc.identifier.wosWOS:000873705600001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPolymers
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectchondroitin sulfate (CS)
dc.subjectpolyelectrolyte microgels
dc.subjectbiocompatible
dc.subjectrosmarinic acid
dc.subjectantioxidant
dc.titlePolyelectrolyte Chondroitin Sulfate Microgels as a Carrier Material for Rosmarinic Acid and Their Antioxidant Ability
dc.typeArticle

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