Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide

Basit Öğe Kaydı
dc.authorid0000-0003-2515-5490en_US
dc.authorid0000-0002-4809-5809en_US
dc.authorscopusid55866023400en_US
dc.authorscopusid36663141300en_US
dc.authorwosidAFK-0339-2022en_US
dc.authorwosidAAX-8091-2021en_US
dc.contributor.authorAcar, Ümit
dc.contributor.authorİnanan, Burak Evren
dc.contributor.authorNavruz, Fahriye Zemheri
dc.contributor.authorYılmaz, Sevdan
dc.date.accessioned2024-12-23T11:27:52Z
dc.date.available2024-12-23T11:27:52Z
dc.date.issued2021en_US
dc.departmentFakülteler, Deniz Bilimleri ve Teknolojisi Fakültesi, Su Ürünleri Yetiştiriciliği Bölümü
dc.description.abstractIn this study, effects of different concentrations (0, 5, 10, 20, 30, and 40 mg/L) of glyphosate-based herbicide (GBH) on Nile tilapia (Oreochromis niloticus) were investigated after a 14-day of exposure. After determination of LC50 value, effects of GBH on hematological and serum biochemical parameters in blood samples, DNA damage, lipid peroxidation and catalase activity in liver tissues, expression levels of antioxidant enzyme-related genes (SOD, CAT, GPx, and GST) and immune-related genes (TGF-β, TGF-α and IL1-β) were evaluated. The LC50 value has been found as 44.4 mg/L for GBH. GBH exposure at all concentrations caused alterations in blood parameters. GBH induced oxidative stress in liver and DNA damage in blood. Antioxidant enzyme-related genes were significantly up-regulated to suppress oxidative stress. On the other hand, the expression levels of immune-related genes decreased in fish exposure to particularly ≥20 mg/L GBH.en_US
dc.identifier.citationAcar, Ü., İnanan, B. E., Navruz, F. Z., & Yılmaz, S. (2021). Alterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 249, 109147. https://doi.org/10.1016/j.cbpc.2021.109147en_US
dc.identifier.doi10.1016/j.cbpc.2021.109147
dc.identifier.issn1532-0456
dc.identifier.issn1878-1659
dc.identifier.pmid34332143
dc.identifier.scopus2-s2.0-85112578792
dc.identifier.urihttps://doi.org/10.1016/j.cbpc.2021.109147
dc.identifier.urihttps://hdl.handle.net/20.500.12428/6776
dc.identifier.volume249en_US
dc.identifier.wosWOS:000693443600005
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAcar, Ümit
dc.institutionauthorYılmaz, Sevdan
dc.language.isoen
dc.publisherElsevier Inc.en_US
dc.relation.ispartofComparative Biochemistry and Physiology Part - C: Toxicology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDNA damageen_US
dc.subjectGene expressionen_US
dc.subjectGlyphosateen_US
dc.subjectNile tilapia (Oreochromis niloticus)en_US
dc.subjectOxidative stressen_US
dc.titleAlterations in blood parameters, DNA damage, oxidative stress and antioxidant enzymes and immune-related genes expression in Nile tilapia (Oreochromis niloticus) exposed to glyphosate-based herbicide
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Umit Acar_Makale.pdf
Boyut:
1.27 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Araştırma Makalesi
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.21 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Su Ürünleri Yetiştiriciliği Bölümü Koleksiyonu