Correlation between psoriasis and ZIP2 and ZIP3 Zinc transporters

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dc.contributor.authorKilic, Sevilay
dc.contributor.authorSehitoglu, Hilal Muserref
dc.date.accessioned2025-01-27T20:51:59Z
dc.date.available2025-01-27T20:51:59Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractAims: Psoriasis is a chronic, inflammatory, hyperproliferative skin disease with etiopathogenesis not fully understood. The zinc transporter ZIP2 is associated with keratinocyte differentiation, whereas ZIP3 is associated with T-lymphocyte maturation. In our study, we aimed to show the correlation between psoriasis and ZIP2 and ZIP3 zinc transporters in psoriasis patients. Subjects and Methods: The patient group in the study included 60 patients aged with psoriasis vulgaris and a control group of 60 healthy adults. The levels of ZIP2 (SLC39A2) and ZIP3 (SLC39A3) zinc transporters were determined with the ELISA method. Results were compared with control group values and statistically assessed. Results: When the ZIP2 and ZIP3 levels are compared in controls and psoriasis patients, the levels were observed to significantly increase compared to controls (P < 0.05). When compared to the control group, the results appeared to be statistically significant (P < 0.05). Conclusions: With etiopathogenesis not fully known, there may be an important relationship between psoriasis development and ZIP2 (SLC39A2) and ZIP3 (SLC39A3) zinc transporters in psoriasis vulgaris patients. This situation may be an important result for understanding how the disease develops and in creating new approaches in terms of treatment for this disease without full cure available.
dc.description.sponsorshipCanakkale Onsekiz Mart University; Canakkale Onsekiz Mart University The Scientific Research Coordination Unit [THD-2018-2669]
dc.description.sponsorshipThis research was supported by funds from the Canakkale Onsekiz Mart University. This project has been funded in whole with the Canakkale Onsekiz Mart University The Scientific Research Coordination Unit, Project number: THD-2018-2669.
dc.identifier.doi10.4103/TJD.TJD_29_20
dc.identifier.endpage64
dc.identifier.issn1307-7635
dc.identifier.issn1308-5255
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85100199398
dc.identifier.scopusqualityQ4
dc.identifier.startpage61
dc.identifier.trdizinid369834
dc.identifier.urihttps://doi.org/10.4103/TJD.TJD_29_20
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/369834
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25613
dc.identifier.volume14
dc.identifier.wosWOS:000574898300001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofTurk Dermatoloji Dergisi-Turkish Journal of Dermatology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPsoriasis vulgaris
dc.subjectzinc transporters
dc.subjectZIP2 (SLC39A2)
dc.subjectZIP3 (SLC39A3)
dc.titleCorrelation between psoriasis and ZIP2 and ZIP3 Zinc transporters
dc.typeArticle

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