Synthesis of ?-chloro-?-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates

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dc.authoridDogan, Ozdemir/0000-0003-3724-8942
dc.contributor.authorPolat-Cakir, Sidika
dc.contributor.authorBeksultanova, Nurzhan
dc.contributor.authorDogan, Ozdemir
dc.date.accessioned2025-01-27T20:14:42Z
dc.date.available2025-01-27T20:14:42Z
dc.date.issued2018
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractA series of unactivated racemic and chiral aziridine-2-phosphonates were synthesized by modified Gabriel-Cromwell reaction. Ring opening reaction of the synthesized phosphonates by gaseous HCl provided access to a wide range of biologically interesting novel beta-chloro-alpha-aminophosphonates. All reactions toward each of the above-mentioned products can be conducted regioselectively in high yields. [GRAPHICS] .
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114Z161]; Middle East Technical University (METU)
dc.description.sponsorshipWe thank the Scientific and Technological Research Council of Turkey (TUBITAK, Grant No. 114Z161) and Middle East Technical University (METU) for the financial support.
dc.identifier.doi10.1080/10426507.2018.1513521
dc.identifier.endpage864
dc.identifier.issn1042-6507
dc.identifier.issn1563-5325
dc.identifier.issue12
dc.identifier.scopus2-s2.0-85054600894
dc.identifier.scopusqualityQ3
dc.identifier.startpage858
dc.identifier.urihttps://doi.org/10.1080/10426507.2018.1513521
dc.identifier.urihttps://hdl.handle.net/20.500.12428/21175
dc.identifier.volume193
dc.identifier.wosWOS:000457034300008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofPhosphorus Sulfur and Silicon and The Related Elements
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectAziridine-2-phosphonates
dc.subjectregioselective ring opening
dc.subjectbeta-chloro-alpha-aminophosphonates
dc.titleSynthesis of ?-chloro-?-aminophosphonate derivatives via the regioselective ring opening of unactivated aziridine-2-phosphonates
dc.typeArticle

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