Influence of Helichrysum arenarium on hemocyte-mediated immune responses and phenoloxidase enzyme activity of model organism Galleria mellonella (L.)

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dc.authorid0000-0002-0984-2824en_US
dc.authorid-en_US
dc.authorid0000-0003-0497-8287en_US
dc.authorscopusid57217302216en_US
dc.authorscopusid57835285500en_US
dc.authorscopusid13605209600en_US
dc.authorwosidAAF-3135-2021en_US
dc.authorwosid-en_US
dc.authorwosidAAA-5763-2019en_US
dc.contributor.authorKaya, Serhat
dc.contributor.authorAkkuş, Gülsüm
dc.contributor.authorTürkdoğan, Seranay
dc.contributor.authorGündüz, Bülent
dc.date.accessioned2024-12-19T10:24:58Z
dc.date.available2024-12-19T10:24:58Z
dc.date.issued2021en_US
dc.departmentFakülteler, Fen Fakültesi, Biyoloji Bölümü
dc.description.abstractHelichrysum arenarium (L.) (Asterales:Asteraceae) Moench is a therapeutic plant which contains etheric oil, flavones and flavon glycosides, sterins, bitter substances and tannins having various coumarins. This plant is thought to have important characteristics such as diuretic effect, dropping stones and sand from the kidney, regulating digestive disorders, strengthening the immune system, and having antibiotic and antioxidant effects. Additionally, this plant is traditionally used in liver and biliary tract diseases and also shows anti-inflammatory and detoxifying properties. Model organism Galleria mellonella L. (Lepidoptera:Pyralidae) is an invertebrate species that is frequently used to study the effects of human pathogens and various pesticides, hormones, etc. on immune system. In our study, we examined the effect of various doses of H. arenarium on the hemocyte count and behavior of G. mellonella larvae. According to the findings obtained at the end of our study, H. arenarium caused an increase in hemocyte count with the injection of 0.25% and 0.5% doses compared to the untreated and DMSO groups. At the same time, the 0.25% and 0.5% doses showed a strong encapsulation-melanization response and an increase in phenoloxidase enzyme activity over 24 h compared to the other injected groups. Based on these results, H. arenarium extract has an anti-mitotic activity at high doses (above 0.5%). This effect may be due to the fact that the plant extract supports mitosis at a certain dose, while being toxic when exceeding it.en_US
dc.identifier.citationKaya, S., Akkuş, G., Türkdoğan, S., & Gündüz, B. (2021). Influence of Helichrysum arenarium on hemocyte-mediated immune responses and phenoloxidase enzyme activity of model organism Galleria mellonella (L.). International Journal of Tropical Insect Science, 41(4), 2521–2528. https://doi.org/10.1007/s42690-021-00432-8en_US
dc.identifier.doi10.1007/s42690-021-00432-8
dc.identifier.endpage2528en_US
dc.identifier.issn1742-7584
dc.identifier.issn1742-7592
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85100372072
dc.identifier.startpage2521en_US
dc.identifier.urihttps://doi.org/10.1007/s42690-021-00432-8
dc.identifier.urihttps://hdl.handle.net/20.500.12428/6762
dc.identifier.volume41en_US
dc.identifier.wosWOS:000614124700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKaya, Serhat
dc.institutionauthorAkkuş, Gülsüm
dc.institutionauthorGündüz, Bülent
dc.language.isoen
dc.publisherSpringer Science and Business Media Deutschland GmbHen_US
dc.relation.ispartofInternational Journal of Tropical Insect Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEncapsulation-melanization responsesen_US
dc.subjectGalleria mellonellaen_US
dc.subjectHelichrysum arenariumen_US
dc.subjectHemocyte countsen_US
dc.subjectImmune systemen_US
dc.subjectPhenoloxidaseen_US
dc.titleInfluence of Helichrysum arenarium on hemocyte-mediated immune responses and phenoloxidase enzyme activity of model organism Galleria mellonella (L.)
dc.typeArticle

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