Drug-eluting Vein Graft with Acetylsalicylic Acid-Ticagrelor- Unfractionated Heparin Complex Inhibits Early Graft Thrombosis

Basit Öğe Kaydı
dc.contributor.authorAksit, Ercan
dc.contributor.authorKurt, Tolga
dc.contributor.authorBuyuk, Basak
dc.contributor.authorCokkalender, Omer
dc.date.accessioned2025-01-27T20:29:37Z
dc.date.available2025-01-27T20:29:37Z
dc.date.issued2020
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackground: Bypass graft surgery remains to be an important treatment option for left main and multivessel coronary artery disease. Approximately 2% of saphenous vein grafts are lost immediately after the coronary artery bypass graft operations and 12% in the first month due to thrombosis. Aims: To administer one anticoagulant and two antiplatelet agents in a way that locally affects the vein graft before the bypass operation and to thereby analyse their effects on early graft thrombosis. Study Design: Animal experimentation. Methods: Since ticagrelor was used locally for the first time in this study; its efficacy in combination with other drugs (acetylsalicylic acid, acetylsalicylic acid and ticagrelor, and acetylsalicylic acid + ticagrelor unfractionated heparin) was examined on rats including control (untreated) and sham (pluronic gel) group (n=14 for each group). Before the tunica adventitia layer of the femoral veins was bypassed to the femoral artery, it was coated with the drug-eluting pluronic F-127 gel. The presence or absence of thrombus in the vein graft samples was recorded under light microscopy. In vein graft preparations where thrombus was detected, the thrombus area (mu m(2)) was calculated using the Axiovision software. Immunohistochemical staining was performed with the anti-rat von Willebrand factor polyclonal antibody kit. Results: The number of preparations containing thrombus was significantly lower in the acetylsalicylic acid + ticagrelor + unfractionated heparin group than in the acetylsalicylic acid, control, and sham groups, according to the comparisons made on the Is/ and 3rd days (p=0.00I and 0.02. respectively). von Willebrand factor staining was significantly lower in the acetylsalicylic acid + ticagrelor + unfractionated heparin group than in the other groups on the 3rd day (p=0.005). Conclusion: Locally effective acetylsalicylic acid-ticagrelor-unfractionated heparin complex has been shown to significantly reduce thrombus formation in vein grafts in this experimental model. Local administration of these drugs, which are routinely administered orally just before stent implantations, on the vein graft before the bypass is performed can prevent the loss of vein grafts due to thrombus, thereby reducing the mortality and morbidity of these patients.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University [TSA-2018-2552]
dc.description.sponsorshipThis research was supported by the Scientific Research Projects Coordination Unit of Canakkale Onsekiz Mart University (project no: TSA-2018-2552).
dc.identifier.doi10.4274/balkanmedj.galenos.2020.2020.1.128
dc.identifier.endpage275
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue5
dc.identifier.pmid32353222
dc.identifier.scopus2-s2.0-85089358998
dc.identifier.scopusqualityQ1
dc.identifier.startpage269
dc.identifier.trdizinid380944
dc.identifier.urihttps://doi.org/10.4274/balkanmedj.galenos.2020.2020.1.128
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/380944
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22996
dc.identifier.volume37
dc.identifier.wosWOS:000559013100006
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectAcetyl salicylic acid
dc.subjectheparin
dc.subjecthydrogel
dc.subjectthrombosis
dc.subjectticagrelor
dc.subjectvein bypass graft
dc.titleDrug-eluting Vein Graft with Acetylsalicylic Acid-Ticagrelor- Unfractionated Heparin Complex Inhibits Early Graft Thrombosis
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu