The Effects of Curcuminoids Supplementation on Serum Adipokines: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

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dc.contributor.authorBahrami, Leila Sadat
dc.contributor.authorRahnama, Iman
dc.contributor.authorChambari, Mahla
dc.contributor.authorNorouzy, Abdolreza
dc.contributor.authorKarav, Sercan
dc.contributor.authorArabi, Seyyed Mostafa
dc.contributor.authorSahebkar, Amirhossein
dc.date.accessioned2025-05-29T02:58:09Z
dc.date.available2025-05-29T02:58:09Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractThis umbrella review of randomized clinical trials aims to provide a unique and detailed understanding of curcumin's effects on adipokines, adding a novel perspective to the existing body of research. We carried out a thorough search of international databases up to April 2024, including MEDLINE, SciVerse Scopus, and Clarivate Analytics Web of Science. A random-effects model was utilized to evaluate the impact of curcuminoid on adipokines. The umbrella review incorporated meta-analyses that examined the effects of curcuminoid supplementation on adipokines, presenting associated effect sizes (ES) and confidence intervals (CI). We applied the GRADE and AMSTAR (A Tool for Assessing the Risk of Bias in Systematic Reviews system) to assess the certainty of the evidence and the quality of the systematic reviews. Our analysis of one meta-analysis, including 14 RCTs plus 1 RCT not included in meta-analyses, revealed significant and impactful findings. We found a substantial increase in serum adiponectin levels with curcuminoid supplementation, indicating a positive effect (SMD: 0.9; 95% CI, 0.4 to 1.3, p < 0.001; I-2 = 92.2%). However, we did not observe a significant impact on serum leptin. The GRADE assessment supports the effect of curcuminoids on adiponectin with moderate evidence, while the impact on leptin was supported by low evidence. Curcuminoid supplementation significantly increases serum adiponectin levels with moderate-quality evidence and has no significant impact on serum leptin. This provides evidence as to the safety and effectiveness of curcuminoids in enhancing adiponectin without adverse effects, reassuring the audience about their potential in adipokine research.
dc.description.sponsorshipNeyshabur University of Medical Sciences
dc.description.sponsorshipThis research received support from the Neyshabur University of Medical Sciences. While preparing this work, the author(s) utilized the QuillBot premium, and Monica AI to proofread and enhance our manuscript's English proficiency. This helped improve our work's readability and made it more accessible to a broader audience. After using these tools, the author(s) carefully reviewed and edited the content as required and took complete responsibility for the publication's content.
dc.identifier.doi10.1002/ptr.8471
dc.identifier.issn0951-418X
dc.identifier.issn1099-1573
dc.identifier.pmid40109154
dc.identifier.scopus2-s2.0-105000556376
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/ptr.8471
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30291
dc.identifier.wosWOS:001449360400001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofPhytotherapy Research
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectadipokine
dc.subjectadiponectin level
dc.subjectcurcuminoids
dc.subjectleptin level
dc.subjectphytomedicine
dc.subjectumbrella meta-analysis
dc.titleThe Effects of Curcuminoids Supplementation on Serum Adipokines: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials
dc.typeReview

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