Assessment of genetic damage induced by gadolinium-based radiocontrast agents

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dc.authorid0000-0001-9640-3354en_US
dc.authorscopusid57195554629en_US
dc.authorwosid-en_US
dc.contributor.authorÇobanoğlu, Hayal
dc.date.accessioned2025-02-06T08:27:31Z
dc.date.available2025-02-06T08:27:31Z
dc.date.issued2022en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractBackground: Today, although gadolinium based contrast agents have been frequently used in the field of medicine, there is limited data available whether gadolinium based agents affect the genome. Aim: The present study aimed to investigate the genotoxic and cytotoxic potentials of gadoteric acid and gadoversetamide used as gadolinium-based contrast agents for magnetic resonance (MR) imaging. Material and methods: The cytokinesis-block micronucleus assay was applied to human peripheral blood lymphocytes to assess the genotoxicity measured as micronucleus (MN), nucleoplasmic bridge (NPBs) and nuclear bud (NBUDs) frequencies. Furthermore, cytokinesis-block proliferation index (CBPI) was calculated to determine cytostasis. Lymphocytes were treated with gadoteric acid at concentrations of 1.0, 2.5, 5.0, and 25 mM and with gadoversetamide at concentrations of 0.25, 1.0, 2.5, and 5.0 mM for 48 h. Results: Gadoteric acid did not cause significant increase in MN, NBPs and NBUDs frequencies and CBPI values at any concentration. Gadoversetamide induced significantly increase MN formation at concentration of 2.5 mM, NBP formation at concentrations of 1.0 and 2.5 mM, and NBUD formation at concentrations of 0.25, 1.0 and 2.5 mM. Additionally, gadoversetamide exposure resulted in statistically significant decrease in CBPI values compared to the control at concentrations of 2.5 and 5.0 mM. In addition, CBPI levels in response to concentrations of gadoversetamide was negatively and significantly associated with concentration. Conclusion: These findings show that gadoteric acid does not have genotoxic or cytotoxic potential, while gadoversetamide might have both genotoxic and cytotoxic potential on human peripheral blood lymphocytes. As a comparison, gadoversetamide was found more genotoxic and cytotoxic.en_US
dc.identifier.citationÇobanoğlu, H. (2022). Assessment of genetic damage induced by gadolinium-based radiocontrast agents. Journal of Trace Elements in Medicine and Biology, 70. https://doi.org/10.1016/j.jtemb.2021.126914en_US
dc.identifier.doi10.1016/j.jtemb.2021.126914en_US
dc.identifier.issn0946-672X / 1878-3252
dc.identifier.pmidPMID: 34953388en_US
dc.identifier.scopus2-s2.0-85121649085en_US
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.jtemb.2021.126914
dc.identifier.urihttps://hdl.handle.net/20.500.12428/29551
dc.identifier.volume70en_US
dc.identifier.wosWOS:000777738300002en_US
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇobanoğlu, Hayal
dc.institutionauthorid0000-0001-9640-3354
dc.language.isoengen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofJournal of Trace Elements in Medicine and Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGadoliniumen_US
dc.subjectGadoteric aciden_US
dc.subjectGadoversatamideen_US
dc.subjectMicronucleusen_US
dc.subjectNuclear buden_US
dc.subjectNucleoplasmic bridgeen_US
dc.titleAssessment of genetic damage induced by gadolinium-based radiocontrast agentsen_US
dc.typearticleen_US

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