The association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction

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dc.contributor.authorGazi, Emine
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorAltun, Burak
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorBekler, Adem
dc.contributor.authorGungor, Omer
dc.contributor.authorYener, Ali Umit
dc.date.accessioned2025-01-27T21:21:20Z
dc.date.available2025-01-27T21:21:20Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjectives: Uric acid (UA) is a strong marker of cardiovascular disease. Therefore, we aimed to determine the relationship between serum UA levels and cardiovascular events in patients in the early period of their acute myocardial infarction. Study design: This retrospective study included 586 consecutive patients with ST-elevated myocardial infarction (STEMI) who were admitted to the hospital between March 2010 and February 2012. The study population was divided into two groups; the first group included hyperuricemic patients (n=107; uric acid level >6 mg/dl in women and >7 mg/dl in men), and the second group included patients with normal UA level (n=479). Multivariate analysis was used to demonstrate the predictive value of UA levels in groups. Results: Patients in the hyperuricemic group were older (median 66 years vs. 60 years, p=0.001), and the ratio of female patients was higher (35.5% vs. 16.9%, p=0.001). Patients with hyperuricemia had a significantly higher incidence of in-hospital cardiovascular mortality than the normal group (15.9% vs. 3.1%, p<0.001). Advanced heart failure (class =3) was more frequent among hyperuricemic patients (17.8% vs. 8.8%, p=0.006). Age =70 years, chest pain duration >6 hours and hyperuricemia (hazard ratio (HR): 1.83, 95% confidence interval: 1.02-3.27; p=0.041) were found to be independent predictors of advanced heart failure. Hyperuricemia was found to be an independent predictor of in-hospital cardiovascular mortality in multivariate analyses (HR: 5.32, 95% confidence interval: 2.4611.49; p=0.001). Conclusion: This study showed that a high serum UA level is an independent predictor of cardiovascular mortality and morbidity during the in-hospital period of STEMI.
dc.identifier.doi10.5543/tkda.2014.65507
dc.identifier.endpage508
dc.identifier.issn1016-5169
dc.identifier.issue6
dc.identifier.pmid25362938
dc.identifier.scopus2-s2.0-84931026205
dc.identifier.scopusqualityQ3
dc.identifier.startpage501
dc.identifier.trdizinid162325
dc.identifier.urihttps://doi.org/10.5543/tkda.2014.65507
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/162325
dc.identifier.urihttps://hdl.handle.net/20.500.12428/28907
dc.identifier.volume42
dc.identifier.wosWOS:000421948900001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTurkish Soc Cardiology
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives of The Turkish Society of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectBiological markers/blood
dc.subjectcardiovascular diseases/mortality
dc.subjectheart failure
dc.subjectmyocardial infarction
dc.subjecturic acid/blood
dc.titleThe association between serum uric acid level and heart failure and mortality in the early period of ST-elevation acute myocardial infarction
dc.typeArticle

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