Light-Activated Modified Arginine Carbon Dots as Antibacterial Particles

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dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.authoridYılmaz, Aynur Sanem / 0000-0002-5260-7678
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorYılmaz, Aynur Sanem
dc.contributor.authorAyyala, Ramesh S.
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2025-01-27T20:54:05Z
dc.date.available2025-01-27T20:54:05Z
dc.date.issued2022
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractNitrogen-doped arginine carbon dots (Arg CDs) as light-sensitive antibacterial agents were prepared by using citric acid as the carbon source and arginine amino acid as the nitrogen source via a microwave-assisted synthesis method. Dynamic light scattering (DLS) measurements and TEM images revealed that the Arg CDs were in the 1-10 nm size range with a graphitic structure. To improve their antibacterial capability, the Arg CDs were modified with ethyleneimine (EDA), pentaethylenehexamine (PEHA), and polyethyleneimine (PEI) as different amine sources, and the zeta potential value of +2.8 +/- 0.6 mV for Arg CDs was increased to +34.4 +/- 4.1 mV for PEI-modified Arg CDs. The fluorescence intensity of the Arg CDs was significantly enhanced after the modification with EDA, and the highest antibacterial effect was observed for the PEI-modified Arg CDs. Furthermore, the photodynamic antibacterial capacity of bare and EDA-modified Arg CDs was determined upon light exposure to show their light-induced antibacterial effects. Photoexcited (315-400 nm, UVA, 300 W), EDA-modified Arg CDs at 5 mg/mL concentration were found to inhibit about 49 +/- 7% of pathogenic bacteria, e.g., Escherichia coli, with 5 min of light exposure. Furthermore, the biocompatibilities of the bare and modified Arg CDs were also investigated with blood compatibility tests via hemolysis and blood clotting assays and cytotoxicity analysis on L929 fibroblast cells.
dc.description.sponsorshipScientific Research Commission of Canakkale Onsekiz Mart University [FIA-2022-3667]
dc.description.sponsorshipThe Scientific Research Commission of Canakkale Onsekiz Mart University FIA-2022-3667 is greatly acknowledged.
dc.identifier.doi10.3390/catal12111376
dc.identifier.issn2073-4344
dc.identifier.issue11
dc.identifier.scopus2-s2.0-85141708514
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/catal12111376
dc.identifier.urihttps://hdl.handle.net/20.500.12428/25971
dc.identifier.volume12
dc.identifier.wosWOS:000883532000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofCatalysts
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectarginine
dc.subjectcarbon dots
dc.subjectmodified carbon dots
dc.subjectphotodynamic antibacterial
dc.subjectUV light
dc.titleLight-Activated Modified Arginine Carbon Dots as Antibacterial Particles
dc.typeArticle

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