The Use of Decellularized Animal Tissues in Regenerative Therapies

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dc.authoridHIZ, Meliha Merve/0000-0003-4303-9717
dc.authoridARSLAN, Yavuz Emre/0000-0003-3445-1814
dc.authoridSezgin Arslan, Tugba/0000-0003-2547-6120
dc.contributor.authorArslan, Yavuz Emre
dc.contributor.authorHiz, Meliha Merve
dc.contributor.authorSezgin Arslan, Tugba
dc.date.accessioned2025-01-27T20:44:19Z
dc.date.available2025-01-27T20:44:19Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractHuman adipose-derived mesenchymal stem cells are nonhematopoietic cells found in the adipose tissue that have multipotent characteristics. Human adipose-derived mesenchymal stem cells have ability to differentiate into multiple lineages, including osteogenic, adipogenic and chondrogenic phenotypes. Because of their high degree of plasticity and ease of isolation, they have a great potential for tissue engineering and regenerative medicine applications. Tissue engineering, using cells, soluble matriks-bound factors and supporting scaffolds, is a promising approach for regeneration, repairing and replacement of malfunctioning tissues and organs. Three-dimensional scaffolds are essential to serve as an adhesive substrate for the transplanted cells and a physical support to guide the formation of new tissues or organs. Particularly, the use of extracellular matrices prepared by decellularized whole tissue and organ as three-dimensional constructs have drawn increasing attention as a tissue engineering strategy. In this context, it is expected that investigating the cellular behaviour of human adipose-derived mesenchymal stem cells on decellularized whole tissue and organ will have a positive impact on regenerative medicine. This review offers a current perspective about decellularization of animal tissues, stem cells' behaviors on obtained matrices and potential use of these matrices in human and/or animal clinic.
dc.identifier.doi10.9775/kvfd.2014.11663
dc.identifier.endpage145
dc.identifier.issn1300-6045
dc.identifier.issue1
dc.identifier.scopus2-s2.0-84910093934
dc.identifier.scopusqualityQ3
dc.identifier.startpage139
dc.identifier.trdizinid165383
dc.identifier.urihttps://doi.org/10.9775/kvfd.2014.11663
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/165383
dc.identifier.urihttps://hdl.handle.net/20.500.12428/24535
dc.identifier.volume21
dc.identifier.wosWOS:000349190200025
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WoS_20250125
dc.subjectDecellularization
dc.subjectExtracellular matrix
dc.subjectAdipose derived mesenchymal stem cell
dc.subjectBiomaterial
dc.subjectTissue engineering
dc.subjectRegenerative medicine
dc.titleThe Use of Decellularized Animal Tissues in Regenerative Therapies
dc.title.alternativeHücrelerinden arındırılmış hayvansal dokuların rejeneratif tedavilerde kullanımı
dc.typeArticle

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