Effect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats

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dc.authorid0000-0002-6474-9032en_US
dc.authorscopusid57196006120en_US
dc.authorwosid-en_US
dc.contributor.authorÇakır, Selcen
dc.date.accessioned2024-02-10T09:50:19Z
dc.date.available2024-02-10T09:50:19Z
dc.date.issued2024en_US
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractBoron (B) is an element that has recently been wondered and researched in many fields, especially due to its effects on energy metabolism. The aim of this study is to evaluate the effect of boric acid (BA) on newly discovered energy metabolism peptides that have not been studied before. In this study, the effects of 15 mg/kg of BA were evaluated in 24 Wistar rats. Groups were named as control group, 15 mg/kg BA group, streptozotocin (STZ)-induced experimental diabetic group, and STZ-induced experimental diabetic + 15 mg/kg BA administered group (STZ+15 mg/kg BA). Serum asprosin, nesfatin-1, preptin, insulin, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), aspartate transaminase (AST), alanine transaminase (ALT), and glucose analyses were performed. In this study, the increase in glucose, TG, TC, LDL-C levels, and AST, ALT activities in STZ-induced groups were reduced with BA administration. While HDL-C level significantly decreased in the STZ group, the level approached the control group values after BA administration (p<0.001). As for peptides, although there was a statistically significant increase after 15 mg/kg BA administration, these levels did not approach the control group values (p<0.001). According to the findings, STZ-induced diabetes mellitus and the biochemical processes that develop accordingly change correlatively. This study showed that BA is effective in energy metabolism.en_US
dc.identifier.citationÇakır, S. (2023). Effect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats. Biological Trace Element Research, 202(3), 1001–1008. https://doi.org/10.1007/s12011-023-03910-xen_US
dc.identifier.doi10.1007/s12011-023-03910-x
dc.identifier.endpage1008en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue3en_US
dc.identifier.pmid37872360
dc.identifier.scopus2-s2.0-85174636625
dc.identifier.startpage1001en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-023-03910-x
dc.identifier.urihttps://hdl.handle.net/20.500.12428/5641
dc.identifier.volume202en_US
dc.identifier.wosWOS:001095803800001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇakır, Selcen
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsprosinen_US
dc.subjectBoric aciden_US
dc.subjectNesfatin-1en_US
dc.subjectPreptinen_US
dc.titleEffect of Boric Acid on Metabolic Peptides and Some Biochemical Parameters in Experimental Diabetic Rats
dc.typeArticle

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