The multifunctional role of bovine colostrum in managing diabetes: clinical insights and potential therapeutic effects

Basit Öğe Kaydı
dc.authorid0000-0001-7509-5487
dc.authorid0000-0003-4056-1673
dc.authorid0000-0002-7722-9466
dc.contributor.authorAiello, Gilda
dc.contributor.authorYalcintas, Yalcin Mert
dc.contributor.authorCampaci, Diego
dc.contributor.authorLombardo, Mauro
dc.contributor.authorMuthanna, Fares M. S.
dc.contributor.authorConte, Caterina
dc.contributor.authorKarav, Sercan
dc.date.accessioned2026-02-03T12:02:50Z
dc.date.available2026-02-03T12:02:50Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractDiabetes mellitus is a global metabolic disorder characterised by insulin resistance or insufficient insulin production, leading to chronic hyperglycemia and severe complications. Although pharmacological treatments exist, there is a growing interest in complementary therapies to improve glycaemic control and attenuate disease progression. Bovine colostrum, a nutrient-rich secretion produced after parturition, contains bioactive compounds such as insulin-like growth factor-1 (IGF-1), lactoferrin, cytokines and immunoglobulins, which have potential therapeutic effects on diabetes. The aim of the review is to report on the various molecular mechanisms through which bovine colostrum is involved in diabetes management. The review analyzes, through clinical studies and potential therapeutic effects, the influence of colostrum on glucose metabolism, insulin sensibility, oxidative stress, and inflammatory processes. Preclinical and clinical evidence suggests that bovine colostrum supplementation can lower blood glucose levels, improve lipid profiles and enhance immune modulation in type 1 and type 2 diabetes. In addition, its role in healing wounds and injuries has been demonstrated in a number of studies that have demonstrated the efficacy of bovine colostrum. Furthermore, its role in wound healing and regulation of the gut microbiota highlights its potential as an adjunctive therapy for diabetes management. Further research is needed to standardise formulations and determine optimal dosages for clinical applications.
dc.description.sponsorshipItalian Ministry of Health [Ricerca Corrente]
dc.description.sponsorshipFinanziamento competitivo di progetti di ricerca
dc.description.sponsorshipThis research was funded by funding from the Italian Ministry of Health [Ricerca Corrente]. Finanziamento competitivo di progetti di ricerca (FIN/RIC) 2023.
dc.identifier.doi10.1007/s40200-025-01683-9
dc.identifier.issn2251-6581
dc.identifier.issue2
dc.identifier.pmid40746620
dc.identifier.scopus2-s2.0-105011950947
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1007/s40200-025-01683-9
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34889
dc.identifier.volume24
dc.identifier.wosWOS:001538724100001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Int Publ Ag
dc.relation.ispartofJournal of Diabetes and Metabolic Disorders
dc.relation.publicationcategoryDiğer
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectDiabetes
dc.subjectBovine colostrum
dc.subjectInsulin resistance
dc.subjectBioactive peptides
dc.subjectInflammation
dc.subjectGlycemic control
dc.titleThe multifunctional role of bovine colostrum in managing diabetes: clinical insights and potential therapeutic effects
dc.typeReview

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu