Tannic acid-based bio-MOFs with antibacterial and antioxidant properties acquiring non-hemolytic and non-cytotoxic characteristics

Basit Öğe Kaydı
dc.authoridŞahiner, Nurettin / 0000-0003-0120-530X
dc.authoridSağbaş Suner, Selin / 0000-0002-3524-0675
dc.authoridŞahiner, Mehtap / 0000-0001-8666-7954
dc.contributor.authorŞahiner, Nurettin
dc.contributor.authorGüven, Olgun
dc.contributor.authorDemirci, Şahin
dc.contributor.authorSağbaş Suner, Selin
dc.contributor.authorŞahiner, Mehtap
dc.contributor.authorArı, Betül
dc.contributor.authorCan, Mehmet
dc.date.accessioned2025-05-29T02:58:01Z
dc.date.available2025-05-29T02:58:01Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractTannic acid (TA) based bio-metal phenolic networks (bio-MPNs) were prepared by using Cu(II), Zn(II), Bi(III), Ce(III), La(III), and Ti(IV) metal ions. TA-based bio-MPNs exhibited wedge-shaped pores between 16.4 and 25.8 nm pore size ranges. The higher gravimetric yield% was achieved for TA-Bi(III), and TA-Ti(IV) bio-MPNs with more than 90 %, and higher surface area was observed for TA-La(IIII) bio-MPNs as 56.2 m(2)/g with 17.3 nm average pore sizes. All TA-based MPNs are non-hemolytic with less than 5 % hemolysis ratio, whereas TA-based Bio-MPNs do not affect blood clotting with > 90 % blood clotting indexes except for TA-Cu(II) Bio-MPNs at 0.1 mg/mL concentration. Moreover, TA-Bi(III) and TA-Ce(III) Bio-MPNs were found to be safer materials showing no significant toxicity on L929 fibroblast cells at 100 mu g/mL concentration, along with TA-based Bio-MPNs prepared with Cu(II), Zn(II), La(III), and Ti(IV) metal ions that could be safely used in in vivo applications at 1 mu g/mL concentration. It has been proven by 2 different antioxidant tests that the prepared TA-based Bio-MPNs show antioxidant properties even if their TA-derived antioxidant properties decrease. Furthermore, all types of TA-based Bio-MPNs show great antimicrobial activity depending on the metal ion or microorganism types and the highest antibacterial/antifungal effect was determined for TA-Cu(II), and TA-Zn(II) Bio-MPNs with the lowest MBC/MFC values against Pseudomonas aeruginosa ATCC 10145, Bacillus subtilis ATCC 6633, and Candida albicans ATCC 10231.
dc.identifier.doi10.1016/j.colsurfb.2025.114669
dc.identifier.issn0927-7765
dc.identifier.issn1873-4367
dc.identifier.pmid40174536
dc.identifier.scopus2-s2.0-105001417666
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.colsurfb.2025.114669
dc.identifier.urihttps://hdl.handle.net/20.500.12428/30244
dc.identifier.volume252
dc.identifier.wosWOS:001461442500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofColloids and Surfaces B-Biointerfaces
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20250529
dc.subjectTannic acid chelates
dc.subjectMetal phenolic networks
dc.subjectTannic acid-metal interactions
dc.subjectAntioxidant bio-MOF
dc.subjectHemocompatible metal phenolic networks
dc.titleTannic acid-based bio-MOFs with antibacterial and antioxidant properties acquiring non-hemolytic and non-cytotoxic characteristics
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Nurettin Sahiner_Makale.pdf
Boyut:
2.99 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyomühendislik Bölümü Koleksiyonu
Kimya Bölümü Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu