Is the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?

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dc.contributor.authorOgretmen, Zerrin
dc.contributor.authorHiz, Merve Meliha
dc.contributor.authorSılan, Fatma
dc.contributor.authorKosar, Sule
dc.contributor.authorÖzdemir, Öztürk
dc.date.accessioned2025-01-27T20:14:09Z
dc.date.available2025-01-27T20:14:09Z
dc.date.issued2014
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractBackround and Design: Psoriasis is a common inflammatory dermatological disease which may be complicated with joint involvement. It has been suggested that there is an association between HLA-B27 positivity and early onset psoriasis. The purpose of the current study was to investigate the incidence of HLA-B27 positivity in psoriasis patients with arthritis. Materials and Methods: In a total of 96 patients with psoriasis, age of onset, family history, and Psoriasis Area and Severity Index (PAS!) values were recorded. The patients were evaluated with regard to physical examination (presence of arthritis), acute phase reactants, HLA-B27 positivity and joint radiographs. Control group comprised of 100 randomly selected healthy individuals. Results: Thirty (31.250%) patients were with psoriasis alone, 66(68.75%) were with the findings of psoriasis and arthritis. Of the 66 patients, 17 (17.708%) were symptomatic (clinical and radiologic findings) and 49 (51.042%) subjects were asymptomatic (radiologic findings only). Nine patients (6 with psoriasis only and 3 with psoriatic arthritis) and 2 healthy controls were positive for HLA-B27. Conclusion: To carry HLA-B27 antigen increased the risk of psoriasis with an OR of 5.06, and clinically proven psoriatic arthritis with an OR of 10.5 compared to healthy controls. These results need confirmation in a larger group of patients with the inclusion of proper positive and healthy controls.
dc.identifier.doi10.4274/turkderm.46338
dc.identifier.endpage134
dc.identifier.issn1019-214X
dc.identifier.issn1308-6294
dc.identifier.issue3
dc.identifier.scopus2-s2.0-84910683081
dc.identifier.scopusqualityN/A
dc.identifier.startpage131
dc.identifier.trdizinid165124
dc.identifier.urihttps://doi.org/10.4274/turkderm.46338
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/165124
dc.identifier.urihttps://hdl.handle.net/20.500.12428/20966
dc.identifier.volume48
dc.identifier.wosWOS:000350177700005
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isotr
dc.publisherDeri Zuhrevi Hastaliklar Dernegi
dc.relation.ispartofTurkderm-Turkish Archives of Dermatology and Venerology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectPsoriasis
dc.subjectpsoriatic arthritis
dc.subjectHLA-B27
dc.subjectseronegative spondylarthropathies
dc.titleIs the HLA B27 genotype a risc faktor for psoriatic arthritis and psoriasis vulgaris?
dc.title.alternativeHLA B27 genotipi psoriasis ve psoriatik artrit için risk faktörü müdür?
dc.typeArticle

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