The Effect of Oleuropein on the Treatment of Allergic Rhinitis

Basit Öğe Kaydı
dc.authorid0000-0001-8737-2891
dc.contributor.authorCil, Ozge Caglar
dc.contributor.authorBuyuk, Basak
dc.contributor.authorEroglu, Huseyin Avni
dc.contributor.authorSehitoglu, Hilal
dc.date.accessioned2026-02-03T12:02:28Z
dc.date.available2026-02-03T12:02:28Z
dc.date.issued2025
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractIntroduction Allergic rhinitis is a disease that negatively affects social and work life and sometimes does not respond to many treatments. Therefore, new treatments are needed. For the prevention and treatment of allergies, oleuropein has been emphasized, and positive results have been shown in the literature. Objective To investigate the effects of general and topical oleuropein during the allergic rhinitis period and the histopathological changes in the nasal mucosa compared with steroid nasal sprays and control group in rats. Methods We developed an experimental animal model with 44 rats divided into 6 groups. Except for the control group, the allergic rhinitis in the other five groups was created with ovalbumin. As treatment, saline was administered to group 3, steroids, to group 4, oleuropein, to group 5, and steroids and oleuropein were administered to group 6. The effects of the drugs were examined histopathologically and the levels of immunoglobulin E (IgE) in the blood were compared. Results Considering the symptomatic findings in rats, we could observe that allergic rhinitis occurred. Based on the IgE levels and histopathological findings, we have statistically shown that oleuropein may be effective in treatment of allergy rhinitis. Conclusion Oleuropein has been shown to be useful in the treatment of allergic rhinitis in an animal model, but further studies are needed before it is introduced into the medical practice.
dc.description.sponsorshipTurkiye Bilim Teknik ve Arastirma Kurumu (TUBITAK) 3001 project [317S048]
dc.description.sponsorshipThe authors declare that the present study was conducted with the support of Turkiye Bilim Teknik ve Arastirma Kurumu (TUBITAK) 3001 project (no: 317S048).
dc.identifier.doi10.1055/s-0045-1809644
dc.identifier.endpage7
dc.identifier.issn1809-9777
dc.identifier.issn1809-4864
dc.identifier.issue3
dc.identifier.pmid40842708
dc.identifier.scopus2-s2.0-105013875215
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1055/s-0045-1809644
dc.identifier.urihttps://hdl.handle.net/20.500.12428/34771
dc.identifier.volume29
dc.identifier.wosWOS:001554455700003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherGeorg Thieme Verlag Kg
dc.relation.ispartofInternational Archives of Otorhinolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260130
dc.subjectallergic rhinitis
dc.subjectoleuropein
dc.subjectsteroid
dc.subjecttreatment
dc.subjectovalbumin
dc.titleThe Effect of Oleuropein on the Treatment of Allergic Rhinitis
dc.typeArticle

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