The effect of fructose-induced metabolic syndrome on the histological structure and enteroendocrine cells in duodenum of rats

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dc.authoridYıldız, Mustafa / 0000-0003-4128-8947
dc.contributor.authorYıldız, Mustafa
dc.contributor.authorKum, Şadiye
dc.date.accessioned2025-01-27T20:58:22Z
dc.date.available2025-01-27T20:58:22Z
dc.date.issued2024
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractMetabolic syndrome is a worldwide common disorder that coexists with abdominal obesity, high blood pressure, dyslipidemia, and high blood sugar. The purpose of this investigation was to examine the effects of metabolic syndrome on enteroendocrine cell count and histological structure in duodenum. The rats were separated into control and metabolic syndrome groups. Duodenum tissue sections were stained with hematoxylin-eosin for histomorphological examinations. Additionally, immunohistochemical analysis of duodenum showed the presence of somatostatin and gastrin immunoreactive cells. In duodenum, it was found that villus height, villus width, villus area and thickness of tunica muscularis significantly increased in metabolic syndrome group compared to control group. Similarly, it was observed that the numbers of somatostatin and gastrin immunoreactive cells in duodenum were significantly higher in metabolic syndrome group compared to control group. As a result, it was revealed that metabolic syndrome caused structural disorders in duodenum and changed enteroendocrine cell population. Thus, it can be assumed that intestinal functions may be negatively affected due to metabolic syndrome and digestive physiology may be disrupted.
dc.identifier.doi10.52973/rcfcv-e34320
dc.identifier.issn0798-2259
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85193419436
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.52973/rcfcv-e34320
dc.identifier.urihttps://hdl.handle.net/20.500.12428/26688
dc.identifier.volume34
dc.identifier.wosWOS:001216661700004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Zulia, Facultad Ciencias Veterinarias
dc.relation.ispartofRevista Cientifica-Facultad De Ciencias Veterinarias
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectDuodenum
dc.subjectgastrin
dc.subjectmetabolic syndrome
dc.subjectrat
dc.subjectsomatostatin
dc.titleThe effect of fructose-induced metabolic syndrome on the histological structure and enteroendocrine cells in duodenum of rats
dc.title.alternativeEfecto del síndrome metabólico inducido por fructosa sobre la estructura histológica y las células enteroendocrinas en el duodeno de ratas
dc.typeArticle

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