Comparison of the GRACE risk score and the TIMI risk index in predicting the extent and severity of coronary artery disease in patients with acute coronary syndrome

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dc.contributor.authorBekler, Adem
dc.contributor.authorAltun, Burak
dc.contributor.authorGazi, Emine
dc.contributor.authorTemiz, Ahmet
dc.contributor.authorBarutcu, Ahmet
dc.contributor.authorGungor, Omer
dc.contributor.authorOzkan, Muhammed Turgut Alper
dc.date.accessioned2025-01-27T20:27:36Z
dc.date.available2025-01-27T20:27:36Z
dc.date.issued2015
dc.departmentÇanakkale Onsekiz Mart Üniversitesi
dc.description.abstractObjective: The prognostic value of the Global Registry of Acute Coronary Events (GRACE) risk score (GRS) and the Thrombolysis In Myocardial Infarction (TIMI) risk index (TRI) has been reported in coronary artery disease (CAD) patients. We aimed to evaluate the relationship between the GRS, TRI, and severity of CAD evaluated by SYNTAX score (SS) in patients with acute coronary syndrome (ACS). Methods: Patients with ACS who were admitted to the coronary care unit of our institution were retrospectively evaluated in this study. A total of 287 patients with ACS [154 non-ST elevated ACS (NSTE-ACS), 133 ST elevated myocardial infarction (STEMI)] were included in the study. The GRS and TRI were calculated on admission using specified variables. The severity of CAD was evaluated using the SS. The patients were divided into low (GRS<109)-, intermediate (GRS 109-140)-, and high (GRS>140)-risk groups and group 1 (TRI<17), group 2 (TRI 17-26), and group 3 (TRI>26) according to GRS and TRI scores. A Pearson correlation analysis was used for the relation between GRS, TRI, and SS. Results: Patients with a history of coronary artery bypass surgery, those who had missing data for calculating the GRS and TRI, and those whose systolic blood pressure (SBP) was more than 180 mm Hg or whose diastolic blood pressure (DBP) was more than 110 mm Hg were excluded from the study. Were excluded from the study. There were significant differences in mean age (p<0.001), heart rate (p<0.001), SS (p<0.001), TRI (p<0.001), rate of NSTE-ACS (p<0.001), and STEMI (p<0.001) in all patients between the risk groups. There was a positive significant correlation between the GRS and the SS (r=0.427, p<0.001), but there were no significant correlation between the TRI and SS (r=0.121, p=0.135). The area under the ROC curve value for GRS was 0.65 (95% CI: 0.56-0.74, p=0.001) in the prediction of severity of CAD. Conclusion: The GRS is more associated with SS than TRI in predicting the severity of CAD in patients with ACS.
dc.identifier.doi10.5152/akd.2014.5802
dc.identifier.endpage806
dc.identifier.issn2149-2263
dc.identifier.issn2149-2271
dc.identifier.issue10
dc.identifier.pmid25592101
dc.identifier.scopus2-s2.0-84988499110
dc.identifier.scopusqualityN/A
dc.identifier.startpage801
dc.identifier.trdizinid232428
dc.identifier.urihttps://doi.org/10.5152/akd.2014.5802
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/232428
dc.identifier.urihttps://hdl.handle.net/20.500.12428/22733
dc.identifier.volume15
dc.identifier.wosWOS:000362968700004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKare Publ
dc.relation.ispartofAnatolian Journal of Cardiology
dc.relation.publicationcategoryinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WoS_20250125
dc.subjectacute coronary syndrome
dc.subjectGRACE risk score
dc.subjectSYNTAX score
dc.subjectTIMI risk index
dc.titleComparison of the GRACE risk score and the TIMI risk index in predicting the extent and severity of coronary artery disease in patients with acute coronary syndrome
dc.typeArticle

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